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Open AccessFeature PaperReview

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

Department of Pharmacy, Università di Genova, 16147 Genova, Italy
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Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(10), 3353; https://doi.org/10.3390/app10103353
Received: 6 April 2020 / Revised: 26 April 2020 / Accepted: 8 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue Functional Foods and Food Supplements)
Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful for the prevention and treatment of cancer, cardiovascular pathologies, and neurodegenerative disorders. Its protective role justifies numerous attempts to include it in functional food preparations and in dietary supplements, and not only to limit the unpleasant collateral effects of chemotherapy. However, ellagic acid use as a chemopreventive agent has been debated because of its poor bioavailability associated with low solubility, limited permeability, first pass effect, and interindividual variability in gut microbial transformations. To overcome these drawbacks, various strategies for oral administration including solid dispersions, micro and nanoparticles, inclusion complexes, self-emulsifying systems, and polymorphs were proposed. Here, we listed an updated description of pursued micro and nanotechnological approaches focusing on the fabrication processes and the features of the obtained products, as well as on the positive results yielded by in vitro and in vivo studies in comparison to the raw material. The micro and nanosized formulations here described might be exploited for pharmaceutical delivery of this active, as well as for the production of nutritional supplements or for the enrichment of novel foods. View Full-Text
Keywords: ellagic acid; oral administration; bioavailability; microformulations; nanoformulations; solubility enhancement ellagic acid; oral administration; bioavailability; microformulations; nanoformulations; solubility enhancement
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MDPI and ACS Style

Zuccari, G.; Baldassari, S.; Ailuno, G.; Turrini, F.; Alfei, S.; Caviglioli, G. Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid. Appl. Sci. 2020, 10, 3353.

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