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Behav. Sci. 2018, 8(11), 105;

Moral Judgment: An Overlooked Deficient Domain in Multiple Sclerosis?

EA 4391 Excitabilité Nerveuse et Thérapeutique, Université Paris-Est, 94010 Créteil, France
Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor, Assistance Publique—Hôpitaux de Paris, 94010 Créteil, France
Neurology Division, Lebanese American University Medical Center-Rizk Hospital (LAUMC-RH), 1100 Beirut, Lebanon
Author to whom correspondence should be addressed.
Received: 28 September 2018 / Revised: 2 November 2018 / Accepted: 13 November 2018 / Published: 16 November 2018
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Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system through which patients can suffer from sensory, motor, cerebellar, emotional, and cognitive symptoms. Although cognitive and behavioral dysfunctions are frequently encountered in MS patients, they have previously received little attention. Among the most frequently impaired cognitive domains are attention, information processing speed, and working memory, which have been extensively addressed in this population. However, less emphasis has been placed on other domains like moral judgment. The latter is a complex cognitive sphere that implies the individuals’ ability to judge others’ actions and relies on numerous affective and cognitive processes. Moral cognition is crucial for healthy and adequate interpersonal relationships, and its alteration might have drastic impacts on patients’ quality of life. This work aims to analyze the studies that have addressed moral cognition in MS. Only three works have previously addressed moral judgement in this clinical population compared to healthy controls, and none included neuroimaging or physiological measures. Although scarce, the available data suggest a complex pattern of moral judgments that deviate from normal response. This finding was accompanied by socio-emotional and cognitive deficits. Only preliminary data are available on moral cognition in MS, and its neurobiological foundations are still needing to be explored. Future studies would benefit from combining moral cognitive measures with comprehensive neuropsychological batteries and neuroimaging/neurophysiological modalities (e.g., functional magnetic resonance imaging, tractography, evoked potentials, electroencephalography) aiming to decipher the neural underpinning of moral judgement deficits and subsequently conceive potential interventions in MS patients. View Full-Text
Keywords: multiple sclerosis; moral decision-making; social cognition; alexithymia; theory of mind; empathy multiple sclerosis; moral decision-making; social cognition; alexithymia; theory of mind; empathy

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Ayache, S.S.; Chalah, M.A. Moral Judgment: An Overlooked Deficient Domain in Multiple Sclerosis? Behav. Sci. 2018, 8, 105.

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