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Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms

Institute of Medical, Pharmaceutical & Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan
Department of Biochemistry and Applied biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
Department of Public Health, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan
Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan
Author to whom correspondence should be addressed.
Behav. Sci. 2018, 8(11), 102;
Received: 10 October 2018 / Revised: 31 October 2018 / Accepted: 31 October 2018 / Published: 4 November 2018
PDF [778 KB, uploaded 4 November 2018]


Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (p < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression. View Full-Text
Keywords: depressive symptoms; interleukin-17; community-dwelling women depressive symptoms; interleukin-17; community-dwelling women

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Tsuboi, H.; Sakakibara, H.; Minamida, Y.; Tsujiguchi, H.; Matsunaga, M.; Hara, A.; Nakamura, H. Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms. Behav. Sci. 2018, 8, 102.

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