Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats
AbstractThe purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline. In this work, we evaluated the effect of natural aging in rats on the cognitive abilities for hippocampal-dependent tasks. Oxidative metabolism indicators are glutathione (GSH), malondialdehyde (MDA) concentrations, and cytosolic phospholipase A2 (PLA2) activity. In addition, neurotransmitter amino acid (L-Glutamic acid, γ-aminobutyric acid (GABA), DL-Serine and DL-Aspartic acid) concentrations were studied in brain areas such as the frontal cortex (FC) and hippocampus (HPC). The spatial long-term memory revealed significant differences among experimental groups: the aged rats showed an increase in escape latency to the platform associated with a reduction of crossings and spent less time on the target quadrant than young rats. Glutathione levels decreased for analyzed brain areas linked with a significant increase in MDA concentrations and PLA2 activity in cognitive-deficient old rats. We found glutamate levels only increased in the HPC, whereas a reduced level of serine was found in both regions of interest in cognitive-deficient old rats. We demonstrated that age-related changes in redox metabolism contributed with alterations in synaptic signaling and cognitive impairment. View Full-Text
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González-Fraguela, M.E.; Blanco-Lezcano, L.; Fernandez-Verdecia, C.I.; Serrano Sanchez, T.; Robinson Agramonte, M.A.; Cardellá Rosales, L.L. Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats. Behav. Sci. 2018, 8, 93.
González-Fraguela ME, Blanco-Lezcano L, Fernandez-Verdecia CI, Serrano Sanchez T, Robinson Agramonte MA, Cardellá Rosales LL. Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats. Behavioral Sciences. 2018; 8(10):93.Chicago/Turabian Style
González-Fraguela, Maria E.; Blanco-Lezcano, Lisette; Fernandez-Verdecia, Caridad I.; Serrano Sanchez, Teresa; Robinson Agramonte, Maria A.; Cardellá Rosales, Lidia L. 2018. "Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats." Behav. Sci. 8, no. 10: 93.
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