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Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC 501, 1530 3rd Ave S, Birmingham, AL 35294, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 9 May 2013; in revised form: 18 June 2013 / Accepted: 20 June 2013 / Published: 27 June 2013
Abstract: Schizophrenia is a complex chronic mental illness that is characterized by positive, negative and cognitive symptoms. Cognitive deficits are most predictive of long-term outcomes, with abnormalities in memory being the most robust finding. The advent of functional magnetic resonance imaging (fMRI) has allowed exploring neural correlates of memory deficits in vivo. In this article, we will give a selective review of fMRI studies probing brain regions and functional networks that are thought to be related to abnormal memory performance in two memory systems prominently affected in schizophrenia; working memory and episodic memory. We revisit the classic “hypofrontality” hypothesis of working memory deficits and explore evidence for frontotemporal dysconnectivity underlying episodic memory abnormalities. We conclude that fMRI studies of memory deficits in schizophrenia are far from universal. However, the current literature does suggest that alterations are not isolated to a few brain regions, but are characterized by abnormalities within large-scale brain networks.
Keywords: schizophrenia; memory; functional magnetic resonance imaging (fMRI); dorsolateral prefrontal cortex; hippocampus; medial temporal lobe
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Kraguljac, N.V.; Srivastava, A.; Lahti, A.C. Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies. Behav. Sci. 2013, 3, 330-347.
Kraguljac NV, Srivastava A, Lahti AC. Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies. Behavioral Sciences. 2013; 3(3):330-347.
Kraguljac, Nina V.; Srivastava, Annusha; Lahti, Adrienne C. 2013. "Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies." Behav. Sci. 3, no. 3: 330-347.