Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction
Abstract
:1. Introduction
2. Inhibitor of DNA Binding/Differentiation
2.1. Background
2.2. Inhibitor of DNA Binding/Differentiation and Depressive Disorders
2.3. Inhibitor of DNA Binding/Differentiation and Environmental Pollutants
3. Relationship between Environmental Toxicants and Depressive Disorders
4. Genomic Interactions between the Inhibitor of DNA Binding/Differentiation, Environmental Toxicants, and Depression
5. Conclusions
Funding
Conflicts of Interest
References
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Gene Symbol | Gene Name |
---|---|
ATF3 | Activating transcription factor 3 |
CDK2 | Cyclin-dependent kinase 2 |
ELOC | Elongin C |
GATA4 | GATA binding protein 4 |
HSPA1A | Heat shock protein family A (Hsp70) member 1A |
HSPA5 | Heat shock protein family A (Hsp70) member 5 |
HSPA8 | Heat shock protein family A (Hsp70) member 8 |
HSPA9 | Heat shock protein family A (Hsp70) member 9 |
ID1 | Inhibitor of DNA binding 1, HLH protein |
ID2 | Inhibitor of DNA binding 2, HLH protein |
ID3 | Inhibitor of DNA binding 3, HLH protein |
MAPK1 | Mitogen-activated protein kinase 1 |
MAPK3 | Mitogen-activated protein kinase 3 |
SREBF1 | Sterol regulatory element binding transcription factor 1 |
Pathway Name | Gene Count | p-Value | Genes |
---|---|---|---|
TGF-beta signaling pathway | 5 | 9.34 × 10−6 | MAPK1, ID2, ID1, MAPK3, ID3 |
Signaling pathways regulating pluripotency of stem cells | 5 | 7.04 × 10−5 | MAPK1, ID2, ID1, MAPK3, ID3 |
Estrogen signaling pathway | 4 | 5.71 × 10−4 | MAPK1, MAPK3, HSPA1A, HSPA8 |
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Avecilla, V.; Avecilla, A. Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction. Med. Sci. 2019, 7, 7. https://doi.org/10.3390/medsci7010007
Avecilla V, Avecilla A. Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction. Medical Sciences. 2019; 7(1):7. https://doi.org/10.3390/medsci7010007
Chicago/Turabian StyleAvecilla, Vincent, and Andrea Avecilla. 2019. "Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction" Medical Sciences 7, no. 1: 7. https://doi.org/10.3390/medsci7010007