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Med. Sci. 2018, 6(3), 61; https://doi.org/10.3390/medsci6030061

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

1
Department of Clinical Psychology, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
2
Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA
3
Division of Pediatric Infectious Diseases, Bronx-Lebanon Hospital Center, Bronx, NY 10457, USA
*
Author to whom correspondence should be addressed.
Received: 7 July 2018 / Revised: 27 July 2018 / Accepted: 30 July 2018 / Published: 3 August 2018
(This article belongs to the Collection Advances in the Pathogenesis of Neurodegenerative Diseases)
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Abstract

The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure. View Full-Text
Keywords: endocrine disruptor; environmental health sciences; gene-environment; inhibitor of differentiation; neurocognitive disorders endocrine disruptor; environmental health sciences; gene-environment; inhibitor of differentiation; neurocognitive disorders
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Supplementary material

  • Externally hosted supplementary file 1
    Doi: 10.20944/preprints201807.0254.v1
    Link: https://www.preprints.org/manuscript/201807.0254/v1
    Description: Requested to be published as a preprint (preprint.org). Life Sciences: Cell & Developmental Biology section. Published on 7/14/2018.
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Avecilla, A.; Doke, M.; Jovellanos, J.; Avecilla, V. Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders. Med. Sci. 2018, 6, 61.

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