Med. Sci. 2018, 6(3), 61; https://doi.org/10.3390/medsci6030061
Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders
1
Department of Clinical Psychology, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
2
Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USA
3
Division of Pediatric Infectious Diseases, Bronx-Lebanon Hospital Center, Bronx, NY 10457, USA
*
Author to whom correspondence should be addressed.
Received: 7 July 2018 / Revised: 27 July 2018 / Accepted: 30 July 2018 / Published: 3 August 2018
(This article belongs to the Collection Advances in the Pathogenesis of Neurodegenerative Diseases)
Abstract
The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure. View Full-TextKeywords:
endocrine disruptor; environmental health sciences; gene-environment; inhibitor of differentiation; neurocognitive disorders
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Supplementary material
-
Externally hosted supplementary file 1
Doi: 10.20944/preprints201807.0254.v1
Link: https://www.preprints.org/manuscript/201807.0254/v1
Description: Requested to be published as a preprint (preprint.org). Life Sciences: Cell & Developmental Biology section. Published on 7/14/2018.
Share & Cite This Article
MDPI and ACS Style
Avecilla, A.; Doke, M.; Jovellanos, J.; Avecilla, V. Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders. Med. Sci. 2018, 6, 61.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Med. Sci.
EISSN 2076-3271
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert