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Open AccessArticle

HLA Typing and Celiac Disease in Moroccans

National Research Council (CNR)-Institute of Translational Pharmacology, U.O.S. L’Aquila, Via Carducci 32, 67100 L’Aquila, Italy
Mohammed V-Souissi University, 10000 Rabat, Morocco
Medicine C, Department of Gastroenterology, Ibn Sina Hospital, 10000 Rabat, Morocco
Institute National d’Hygiene, 10000 Rabat, Morocco
Author to whom correspondence should be addressed.
Academic Editor: Francesca Megiorni
Med. Sci. 2017, 5(1), 2;
Received: 30 September 2016 / Revised: 7 December 2016 / Accepted: 22 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Genetics of Celiac Disease)
Genetic and environmental factors are responsible for differences in the prevalence of some diseases across countries. Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) has been fast increasing in prevalence in North Africa; but few immunogenetic data are available for this area, in which a high prevalence of the disease has been described. In this report, we assess and discuss results of HLA class II (HLA-DQA1/DQB1/DRB1) typing in Moroccan patients with CD and compare them with a control population from Morocco—genetically well characterized—and with other North African, Mediterranean, and European populations. The classical HLA-DQ associations were confirmed in Moroccans with CD. The high frequency of DQ2.5 homozygosity (45.2%) found in Moroccans with CD was noteworthy as compared with other populations (23%–32%). The genetic risk gradient for CD, identified by previous studies, has been confirmed in Moroccans with some differences, mainly concerning DQ8 genotypes. This study provides the immunogenetic framework of CD in Moroccans and confirms the need to learn more about associations with additional HLA and non-HLA genetic factors. View Full-Text
Keywords: celiac disease; HLA; Morocco; population; North Africa celiac disease; HLA; Morocco; population; North Africa
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MDPI and ACS Style

Piancatelli, D.; Ben El Barhdadi, I.; Oumhani, K.; Sebastiani, P.; Colanardi, A.; Essaid, A. HLA Typing and Celiac Disease in Moroccans. Med. Sci. 2017, 5, 2.

AMA Style

Piancatelli D, Ben El Barhdadi I, Oumhani K, Sebastiani P, Colanardi A, Essaid A. HLA Typing and Celiac Disease in Moroccans. Medical Sciences. 2017; 5(1):2.

Chicago/Turabian Style

Piancatelli, Daniela; Ben El Barhdadi, Imane; Oumhani, Khadija; Sebastiani, Pierluigi; Colanardi, Alessia; Essaid, Abdellah. 2017. "HLA Typing and Celiac Disease in Moroccans" Med. Sci. 5, no. 1: 2.

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