Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy—An Updated Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Inclusion Criteria
2.2.1. Participants
2.2.2. Intervention
2.2.3. Comparison
2.2.4. Outcomes
2.2.5. Study Design
2.3. Exclusion Criteria
2.4. Data Collection Process
2.5. Data Synthesis and Analysis
2.6. Risk of Bias and Study Quality Assessment
3. Results
3.1. Studies and Settings
3.2. Description of the Studies
3.3. Study Results
3.4. Risk of Bias Assessment
4. Discussion
5. Conclusions
- (1)
- The risk of recurrence is similar in patients treated with ED and SP.
- (2)
- The transient facial nerve palsy rate is lower after ED, while the permanent facial nerve palsy rate is similar for ED and SP.
- (3)
- Post-operative complications, especially Frey’s syndrome, are more common after SP.
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Title, Year | Study Design | No. Patients | Mean Age | Mean Follow Up (Range) (ED/SP) | Mean Tumor Size (Range) (ED/SP) | Localization | ED | SP | Capsular Rupture (ED/SP) | Transient Facial Narve Palsy (ED/SP) | Permanent Facial Nerve Palsy (ED/SP) | Frey’s Syndrome (ED/SP) | Salivary Fistula (ED/SP) | Sialocele (ED/SP) | Seroma (ED/SP) | Hematoma (ED/SP) | Recurrence (ED/SP) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Roh JL et al., 2024 [17] | Prospective | 36 | 54 | 44 mo (24–60) | 2.8 cm | Deep or superficial parotid lobe | 36 | 0 | 2 | 0 | 3 | 4 | 0 | ||||
Chidambaram KS et al., 2023 [35] | Retrospective | 33 | 32.75 | (2–43) mo | (2–4) cm | Mainly the tail of the superficial lobe, with some having minimal superior or deep lobe extension | 33 | 0 | 0 | 1 | 0 | ||||||
Barca I et al., 2020 [34] | Retrospective | 261 | 47 | 65 mo | 2.5/2.8 cm | Superficial parotid lobe with a diameter of 3.0 (0.5) cm | 210 | 51 | 7/3 | 7/9 | 0/2 | 0/0 | 1/1 | 6/3 | |||
Qin H et al., 2020 [36] | Retrospective | 75 | 24 mo | Superficial parotid lobe | 37 | 2 | 3 | ||||||||||
Bonavolontà P et al., 2019 [33] | Retrospective | 297 | 52 | 43 (25–168) mo * | ED: superficial parotid lobe SP: deep parotid lobe | 194 | 89 | 3/21 | 0/6 | 2/6 | 2/4 | 3/5 | 15/8 | 8/4 | |||
Schaper M et al., 2019 [32] | Retrospective | 205 | 48 | 7.9 y | Deep or superficial parotid lobe | 77 | 2 | 0 | 4 | 2 | |||||||
Espinosa CA et al., 2018 [31] | Retrospective | 198 | 46.18 | 56.7 (1–437) mo | 2.1 cm | 180: superficial parotid lobe 18: deep parotid lobe | 165 | 78 | 10 | ||||||||
Infante-Cossio P et al., 2018 [18] | Prospective | 79 | 48 | 30.65 (12–45) mo | 2.44 (1–6) cm | Superficial parotid lobe | 79 | 41 | 0 | 9 | 0 | 0 | 0 | 10 | |||
Ogreden S et al., 2016 [30] | Retrospective | 50 | 5 y | Superficial parotid lobe | 18 | 1 | 5 | 0 | |||||||||
Cristofaro MG et al., 2014 [29] | Retrospective | 198 | 50.97 | 61.02/66.4 mo | 3.0/2.5 cm | Superficial parotid lobe | 153 | 45 | 6/1 | 7/9 | 0/1 | 1/1 | 5/1 | ||||
Iro H et al., 2012 [28] | Retrospective | 76 | 51.35 | 7.38 (5.05–10.52) y | Superficial parotid lobe | 76 | 6 | 2 | 2 | 0 | |||||||
Fukushima M et al., 2011 [27] | Retrospective | 31 | 43 | 61 (18–125) mo | 2.8 cm | Deep or superficial parotid lobe | 31 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | ||
Riad MA et al., 2011 [20] | Prospective | 164 | 49.5 | 56.4 (34–93) mo | 141: superficial parotid lobe 19: deep parotid lobe 22: parapharyngeal space | 77 | 1 | 2 | |||||||||
Uyar Y et a l., 2011 [19] | Prospective | 41 | 48.8 | 194 (117–264) mo | Superficial parotid lobe | 21 | 20 | 0/3 | 0/1 | 0/3 | 0/0 | ||||||
Guntinas O et al., 2004 [13] | Retrospective | 295 | 253 | 8 y | Deep or superficial parotid lobe | 150 | 1 | 58 | 7 | 4 | 3 | 17 | 0 | ||||
Piekarski J et al., 2004 [26] | Retrospective | 98 | 34.3 mo | 3.6 (1.5–10) mo | N/A | 98 | 7 | 8 | 8 | ||||||||
Gosh S et al., 2003 [25] | Retrospective | 83 | 49.4 | 10.6 mo (0–10.5 y) | N/A | 22 | 49 | 1/3 | |||||||||
Hancock BD et al., 1999 [24] | Retrospective | 101 | 43/46 | 10.3 (3–21)/8.3 (3–22) y | N/A | 28 | 73 | 0/0 | 2/6 | 0/0 | 0/18 | 0/0 | |||||
Laskawi R et al., 1996 [23] | Retrospective | 475 | 63 mo | N/A | 139 | 2 | 20 | 1 | |||||||||
Leverstein H et al., 1997 [22] | Retrospective | 245 | 95 mo | N/A | 61 | 0 | 8 | 0 | |||||||||
McGurk M et al., 1996 [21] | Retrospective | 475 | 47 | 12.5 (1–34) y | N/A | 380 | 95 | 41/30 | 7/1 | 18/36 | 3/0 | 7/2 |
Study | Selection | Comparison | Outcome |
---|---|---|---|
Roh JL et al., 2024 [17] | xxx | x | xxx |
Chidambaram KS et al., 2023 [35] | xxx | x | xxx |
Barca I et al., 2020 [34] | xx | xx | xx |
Qin H et al., 2020 [36] | xxx | x | xx |
Bonavolontà P et al., 2019 [33] | xxx | xx | xxx |
Schaper M et al., 2019 [32] | xxx | x | xxx |
Espinosa CA et al., 2018 [31] | xxx | xx | xxx |
Infante-Cossio P et al., 2018 [18] | xxx | x | xx |
Ogreden S et al., 2016 [30] | xxx | x | xx |
Cristofaro MG et al., 2014 [29] | xxx | x | xxx |
Iro H et al., 2012 [28] | xxx | x | xxx |
Fukushima M et al., 2011 [27] | xxx | x | xxx |
Riad MA et al., 2011 [20] | xxx | x | xx |
Uyar Y et al., 2011 [19] | xxx | xx | xx |
Guntinas O et al., 2004 [13] | xxx | x | xxx |
Piekarski J et al., 2004 [26] | xxx | x | xxx |
Gosh S et al., 2003 [25] | xxx | x | xxx |
Hancock BD et al., 1999 [24] | xxx | x | xx |
Laskawi R et al., 1996 [23] | xxx | x | xx |
Leverstein H et al., 1997 [22] | xxx | x | xxx |
McGurk M et al., 1996 [21] | xxx | x | xxx |
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Salzano, G.; Scocca, V.; Troise, S.; Abbate, V.; Bonavolontà, P.; Vaira, L.A.; Committeri, U.; Lechien, J.R.; Tramontano, S.; Canterino, V.; et al. Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy—An Updated Systematic Review and Meta-Analysis. Med. Sci. 2025, 13, 104. https://doi.org/10.3390/medsci13030104
Salzano G, Scocca V, Troise S, Abbate V, Bonavolontà P, Vaira LA, Committeri U, Lechien JR, Tramontano S, Canterino V, et al. Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy—An Updated Systematic Review and Meta-Analysis. Medical Sciences. 2025; 13(3):104. https://doi.org/10.3390/medsci13030104
Chicago/Turabian StyleSalzano, Giovanni, Veronica Scocca, Stefania Troise, Vincenzo Abbate, Paola Bonavolontà, Luigi Angelo Vaira, Umberto Committeri, Jerome R. Lechien, Sara Tramontano, Vitanna Canterino, and et al. 2025. "Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy—An Updated Systematic Review and Meta-Analysis" Medical Sciences 13, no. 3: 104. https://doi.org/10.3390/medsci13030104
APA StyleSalzano, G., Scocca, V., Troise, S., Abbate, V., Bonavolontà, P., Vaira, L. A., Committeri, U., Lechien, J. R., Tramontano, S., Canterino, V., & Dell’Aversana Orabona, G. (2025). Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy—An Updated Systematic Review and Meta-Analysis. Medical Sciences, 13(3), 104. https://doi.org/10.3390/medsci13030104