Next Article in Journal
Litter Survival Differences between Divergently Selected Lines for Environmental Sensitivity in Rabbits
Next Article in Special Issue
Dietary 25-Hydroxyvitamin D3 Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs
Previous Article in Journal
Influence of Farming Conditions on the Rumen of Red Deer (Cervus elaphus)
Previous Article in Special Issue
Influence of Traditional vs Alternative Dietary Carbohydrates Sources on the Large Intestinal Microbiota in Post-Weaning Piglets
Article

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

1
Institute of Animal Nutrition, Sichuan Agricultural University, and Key Laboratory of Animal Disease Resistance Nutrition Ministry of Education, Chengdu 611130, Sichuan, China
2
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Dookie Campus, VIC 3647, Australia
3
Sichuan Synlight Biotech Ltd., Chengdu 610041, Sichuan, China
*
Author to whom correspondence should be addressed.
Animals 2019, 9(9), 602; https://doi.org/10.3390/ani9090602
Received: 25 June 2019 / Revised: 19 August 2019 / Accepted: 21 August 2019 / Published: 24 August 2019
(This article belongs to the Collection Gut Microbiota and Growth and Health of Monogastric Farm Animals)
Beta-glucan is currently under consideration as an alternative to in-feed antibiotics for the sustainable pig production industry in China. Modulating intestinal function by β-glucan treatment in young pigs is one potential way of decreasing disease susceptibility and presumably increasing growth performance. In the present study, as a newly developed commercial product, β-glucans have proved to modulate gut function, and have improved growth performance in lipopolysaccharide (LPS)-challenged piglets. The present study aimed to determine the mechanisms involved inβ-glucan of low and high molecular weight mediated growth alterations in weaned piglets. The results confirmed that β-glucans isolated from Agrobacterium sp. ZX09 could improve growth performance in weaned piglets and they showed intestinal modulatory properties via different mechanisms in regulating the mucosal barrier function and microbial populations between two different molecular weight β-glucans.
This study investigated β-glucan derived from Agrobacterium sp. ZX09 with high (2000 kDa) and low (300 kDa) molecular weight (MW) to compare their effects on growth performance and gut function in LPS-induced weaned piglets. Changes in jejunal morphology, mucosal barrier function, microbial populations, and fermentation in the piglets were determined. Data showed that β-glucan prevented body weight loss in LPS challenged piglets. Supplementation with both β-glucan fractions improved jejunal morphology. Compared to low MW, β-glucan of high MW generally up-regulated transcripts of ZO-1, MUC1, and MUC2 in jejunal mucosa to a lesser extent. Mucosal D-lactate, diamine oxidase, and anti-oxidation index were effectively resumed in β-glucan treatment. Both β-glucan diets provoked the emergence of a balanced microbiota and a richer concentration of volatile fatty acids in the colon. The richest community of bifidobacterium and concentration of butyrate emerged after feeding β-glucan with high MW. Results suggested that the effect of Agrobacterium sp. ZX09 β-glucans on the gut-modulatory function is largely linked to their MW. Low MW β-glucan mainly improved the mucosal barrier function in the jejunum, while high MW β-glucan had profound effects on the microbial community and fermentation in the hindgut of piglets. View Full-Text
Keywords: β-glucan; barrier function; microbiota; piglets β-glucan; barrier function; microbiota; piglets
Show Figures

Figure 1

MDPI and ACS Style

Luo, J.; Chen, D.; Mao, X.; He, J.; Yu, B.; Cheng, L.; Zeng, D. Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota. Animals 2019, 9, 602. https://doi.org/10.3390/ani9090602

AMA Style

Luo J, Chen D, Mao X, He J, Yu B, Cheng L, Zeng D. Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota. Animals. 2019; 9(9):602. https://doi.org/10.3390/ani9090602

Chicago/Turabian Style

Luo, Junqiu, Daiwen Chen, Xiangbing Mao, Jun He, Bing Yu, Long Cheng, and Dafu Zeng. 2019. "Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota" Animals 9, no. 9: 602. https://doi.org/10.3390/ani9090602

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop