Next Article in Journal
Motivation of Owners to Purchase Pedigree Cats, with Specific Focus on the Acquisition of Brachycephalic Cats
Previous Article in Journal
Slaughter of Pregnant Cattle in Denmark: Prevalence, Gestational Age, and Reasons
Open AccessArticle

Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons

1
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy
2
Department of Pathology, Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
3
Department of Biology, University of Naples Federico II, Via Cinthia 21, 80126 Naples, Italy
*
Author to whom correspondence should be addressed.
Animals 2019, 9(7), 393; https://doi.org/10.3390/ani9070393
Received: 21 May 2019 / Revised: 10 June 2019 / Accepted: 25 June 2019 / Published: 27 June 2019
(This article belongs to the Section Animal Nutrition)
We tested the effects of a nutraceutical product, DiSeniorTM, by spatial navigation test and by in vitro and in vivo experiments. Results showed that DiSeniorTM was safe and able to ameliorate cognitive functions in aged dogs, as demonstrated by the better performances in the treated with respect the untreated groups. The increase of cFOS, a functional marker of activity in cultured neurons, indicated a positive effect of the substance on neuronal functions. The study suggests that DiSeniorTM can improve the quality of life of elderly dogs and may slow the onset of cognitive dysfunction symptoms associated with aging.
The objective of this research was to investigate the efficacy of DìSeniorTM, a nutraceutical formulated to improve cognitive functions in elderly dogs. To this purpose, some clinical and metabolic investigations and a spatial navigation test were performed in treated and untreated dogs. Moreover, the nutraceutical was also tested on primary hippocampal neuron cultures. Results showed no adverse effects on the dogs’ health and a positive effect on learning. In vitro effects on neuron cultures showed an increase in the level of cFOS in treated neurons compared with the vehicle, suggesting that DiSeniorTM has also a positive effect on neuronal functions. Overall, this study suggests that DiSeniorTM can exert a beneficial effect on aged dogs by preventing the negative effects of aging on cognition. Further studies are needed to assess the mechanisms by which it acts on neurons and the specific effect of the different components alone or combined. View Full-Text
Keywords: dog; aging; cognitive disorders; nutraceuticals; spatial navigation test; cFOS dog; aging; cognitive disorders; nutraceuticals; spatial navigation test; cFOS
Show Figures

Figure 1

MDPI and ACS Style

Pero, M.E.; Cortese, L.; Mastellone, V.; Tudisco, R.; Musco, N.; Scandurra, A.; D’Aniello, B.; Vassalotti, G.; Bartolini, F.; Lombardi, P. Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons. Animals 2019, 9, 393.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop