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Volume 13
Issue 2
10.3390/ani13020289
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Review
Peer-Review Record

Oxidized β-Carotene Is a Novel Phytochemical Immune Modulator That Supports Animal Health and Performance for Antibiotic-Free Production

Animals 2023, 13(2), 289; https://doi.org/10.3390/ani13020289
by William W. Riley 1, James G. Nickerson 2, Trevor J. Mogg 2 and Graham W. Burton 2,*
Reviewer 1:
Kenneth Genovese
Reviewer 2: Anonymous
Animals 2023, 13(2), 289; https://doi.org/10.3390/ani13020289
Submission received: 30 October 2022 / Revised: 6 January 2023 / Accepted: 10 January 2023 / Published: 14 January 2023
(This article belongs to the Special Issue Advances on Alternatives to Conventional Antimicrobials: Implications on Livestock, Aquaculture, and Poultry Production)

Round 1

Reviewer 1 Report

The manuscript describes the use of beta carotenes as an alternative to antimicrobial use in the feed of various livestock species. The review is fairly comprehensive and details the current research concerning the use of these compounds in livestock species through feed. Alternatives to antimicrobials are recognized as possible essential players in the food production industries and are highly sought after to take their place.

The review is concise, covers a broad topic area and thorough.

No other comments from the reviewer are necessary.

Author Response

Thank you for your review.

No response required.

Reviewer 2 Report

I have carefully read the review entitled: “Oxidized β-Carotene is a Novel Phytochemical Immune Modulator that Supports Animal Health and Performance for Antibiotic-Free Production” and believe that the subject may be of interest for publication in Animals.

The fact that OxBCs may have a wider commercial use in the future cannot be excluded a priori and a review in this sense can help evaluate all aspects. At the present time I see this perspective as still not applicable, pending more extensive, inclusive studies and - above all - not before an accurate assessment of any toxicity (even if the current data seem to be reassuring).

It would also be useful to have further information available, such as - for example - the cost per ppm of OxBC, in order to also calculate the economic impact they could have during their use in farm.

It would also be useful to know the stability data of the OxBCs; since the authors include representatives of the Avivagen company, do they have this data?

However, I believe that the antimicrobial effects of OxBCs (via a mechanism of action on the host immune system) still need further study before they can be accredited as innovative and permanent solutions. I suggest a little more caution in the statements, also in the light of some controversial results that the authors themselves presented in their review.

Author Response

See attached file.

Author Response File: Author Response.docx

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