Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update
Abstract
:Simple Summary
Abstract
1. Equine Viral Hepatitis: Overview
2. Equine Hepacivirus (EqHV)
2.1. Classification
2.2. Viral Structure
2.3. Viral Genome
2.4. Viral Replication
3. Epidemiology
3.1. Routes of Transmission
3.1.1. Vertical Transmission
3.1.2. Horizontal Transmission
3.1.3. Parenteral Transmission
The Relevance of Parenteral Transmission, Horse Serum, and Plasma
3.1.4. Other Routes of Transmission (Insect-Mediated and Sexual)
4. Geographical Distribution, Viral Prevalence, and Seroprevalence
4.1. Meta-Analysis
4.1.1. Search Strategy and Study Selection
4.1.2. Data Extraction
4.1.3. Meta-Analysis
5. Individual Risk Factors
5.1. Age
5.2. Breed
5.3. Sex
5.4. Production Category
6. Herd Management Risk Factors
7. EqHV Clinical Presentation
7.1. Hepaciviruses Infection: A Brief Summary
7.2. Acute and Chronic Infection in Horses
7.3. Infection Steps: Protection against Reinfection
8. Cross-Species Transmission
EqHV Cross-Species Transmission
9. Laboratory Diagnosis and Therapy
9.1. Laboratory Diagnosis
9.1.1. Serological Methods
9.1.2. Biomolecular Methods
9.1.3. Other Methods
9.2. Therapy
10. Phylogenetic Analysis
11. EqHV as a Model for HCV
12. Discussion and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hepacivirus Species | A | B | C | D | E | F | G |
Previous identifier | Canine HV, NPHV, EqHV | GBV-B | HCV | Guereza Hepacivirus | Rodent Hepacivirus | Rodent Hepacivirus | Norway Rat HV 1 |
Host | Horse (Dog?) | NW primates | Human | OW Primate | NW Rodent | OW Rodent | Global Rodent |
Hepacivirus species | H | I | J | K | L | M | N |
Previous identifier | Norway Rat HV 2 | Rodent Hepacivirus | Rodent Hepacivirus | Bat Hepacivirus | Bat Hepacivirus | Bat Hepacivirus | Bovine Hepacivirus |
Host | Global Rodent | OW Rodent | OW Rodent | OW bat | OW bat | OW bat | Cow |
Continent | Country | Tested Species | Prevalences (Only Horses) | References | |
---|---|---|---|---|---|
PCR (%) | Serum (%) | ||||
Europe | Italy | Horse, Donkey | 91/1932 (4.7%) | n.d. | Elia et al., 2017 [44] |
Hungary | Horse | 1/1 (100%) | n.d. | Reuter et al., 2014 [18] | |
UK | Horse | 3/142 (2.1%) | n.d. | Lyons et al., 2012 [33] | |
UK | Horse, Donkey | 3/328 (<1%) | 142/328 (43.3%) | Lyons et al., 2014 [38] | |
Germany | Horse | 7/210 (3.3%) | n.d. | Drexler et al., 2013 [43] | |
Germany | Horse | 11/433 (2.5%) | 136/433 (31.4%) | Pfaender et al., 2015 [19] | |
Germany | Horse | 10/119 (8.4%) | n.d. | Postel et al., 2016 [34] | |
Germany | Horse | 134/733 (18.2%) | 453/733 (61.8%) | Reichert et al., 2017 [46] | |
Germany | Horse | 28/1155 (2.4%) | n.d. | Schlottau et al., 2019 [47] | |
Austria | Horse | 16/386 (4.15%) | 177/386 (45.9%) | Badenorst et al., 2019 [42] | |
Austria | Horse, Donkey | 1/259 (0.38%) | n.d. | Badenorst et al., 2021 [48] | |
France | Horse | 69/1229 (5.6%) | n.d. | Pronost et al., 2016 [29] | |
France | Horse, Thoroughbreds | 62/1033 (6.2%) | n.d. | Pronost et al., 2017 [45] | |
Africa | South Africa | Horse, Thoroughbreds | 36/454 (7.9%) | 380/454 (83.70%) | Badenhorst et al., 2018 [49] |
Marocco | Horse | 18/172 (10.50%) | 113/172 (65.70%) | Abbadi et al., 2021 [39] | |
North America | US | Horse | 8/103 (7.7%) | 36/103 (34.9%) | Burbelo et al., 2012 [1] |
US | Horse | 2/14 (14.28%) | n.d. | Tomlinson et al., 2019 [22] | |
South America | Brazil | Horse, Donkey, Mule | 25/265 (9.4%) | n.d. | Gemaque et al., 2014 [50] |
Brazil | Horse, Donkey | 27/202 (13.4%) | n.d. | Figuereido et al., 2015 [51] | |
Brazil | Horse | 31/231 (13.4%) | n.d. | Figuereido et al., 2018 [52] | |
Asia | China | Horse, Donkey, Mule | 6/177 (3.4%) | n.d. | Lu et al., 2016 [55] |
China | Horse | 6/13 (46.2%) | n.d. | Lu et al., 2019 [58] | |
China | Horse, Warmblood | 19/60 (3.2%) | n.d. | Wu et al., 2020 [59] | |
China | Horse | 12/133 (9%) | n.d. | Chen et al., 2021 [60] | |
Mongolia | Horse | 141/299 (47.1%) | n.d. | Date et al., 2020 [26] | |
Japan | Horse | 11/31 (35.6%) | 7/31 (22.6%) | Tanaka et al., 2014 [53] | |
Japan | Horse, Thoroughbreds | 62/453 (13.7%) | 152/453 (33.5%) | Matsuu et al., 2015 [54] | |
Japan | Indigenous breed horses | n.d. | 83/355 (23.9%) | Hayashi et al., 2018 [57] | |
Korea | Horse, Thoroughbreds | 14/74 (18.9%) | n.d. | Kim et al., 2017 [56] | |
Korea | Horse | 13/160 (8.1%) | n.d. | Yoon et al., 2021 [32] | |
Oceania | Australia | Horse | 21/188 (11.2%) | n.d. | Fortier et al., 2021 [61] |
References | Species | Altered Values | Reference Intervals |
---|---|---|---|
Lyons et al., 2012 [33] | Horse | ↑ GGT | GGT < 40 U/mL |
Ramsay et al., 2015 [24] | Horse | ↑ GGT | GGT 14–40 U/L |
↑ SDH | SDH 4–14 U/L | ||
Scheel et al., 2015 [11] | Horse | ↑ GLDH | GLDH 1–8 U/L |
↑ GGT | GGT 8–29 U/L | ||
↑ AST | AST 199–374 U/L | ||
↑ SDH | SDH 0–11 U/L | ||
Gather et al., 2016 [25] | Horse | ↑ GLDH | GLDH < 6 U/L |
↑ GGT | GGT < 20 U/L | ||
↑ AST | AST < 170 U/L | ||
Pfaender et al., 2017 [21] | Horse | ↑ GLDH | GLDH < 6 U/L |
↑ GGT | GGT < 20 U/L | ||
↑ AST | AST < 170 U/L | ||
Tomlinson et al., 2021 [17] | Horse | ↑ GLDH | n.d. |
↑ GGT | n.d. | ||
↑ AST | n.d. | ||
↑ SDH | n.d. |
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Pacchiarotti, G.; Nardini, R.; Scicluna, M.T. Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update. Animals 2022, 12, 2486. https://doi.org/10.3390/ani12192486
Pacchiarotti G, Nardini R, Scicluna MT. Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update. Animals. 2022; 12(19):2486. https://doi.org/10.3390/ani12192486
Chicago/Turabian StylePacchiarotti, Giulia, Roberto Nardini, and Maria Teresa Scicluna. 2022. "Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update" Animals 12, no. 19: 2486. https://doi.org/10.3390/ani12192486
APA StylePacchiarotti, G., Nardini, R., & Scicluna, M. T. (2022). Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update. Animals, 12(19), 2486. https://doi.org/10.3390/ani12192486