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Article

Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling

1
Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-747 Olsztyn, Poland
2
Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, 80-210 Gdansk, Poland
3
Department of Obstetrics and Gynecology, The Medical Center of Postgraduate Education, 02-091 Warsaw, Poland
4
INVICTA Fertility and Reproductive Center, 80-850 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Mário Binelli
Animals 2021, 11(9), 2636; https://doi.org/10.3390/ani11092636
Received: 9 July 2021 / Revised: 27 August 2021 / Accepted: 2 September 2021 / Published: 8 September 2021
(This article belongs to the Section Animal Reproduction)
A article proved that, in rats with PTU-induced hypothyroidism, the E2 level as well as the expression of the uterine-receptivity factors homeobox A10 and osteopontin was decreased. Additionally, we observed changes in the expression of PGE2, PGF, and PGI2 signaling pathway elements, and changes in the concentrations of those prostaglandins in uterine tissue. The results suggest that hypothyroidism may interfere with the prostaglandin signaling pathway, which may further result in a reduction in uterine receptivity.
Thyroid hormones control the functions of almost all body systems. Reproductive dysfunctions, such as abnormal sexual development, infertility, or irregularities in the reproductive cycle, might be associated with thyroid disorders. Uterine receptivity is the period when the uterus is receptive to the implantation of an embryo. During the receptivity period (implantation window), a newly formed blastocyst is incorporated into the uterine epithelium. Prostaglandins are well-known primary mediators of pathological conditions such as inflammation and cancer but are also essential for the physiology of female reproduction. The aim of this study was to evaluate the possible relationship between hypothyroidism and changes in the prostaglandin signaling pathways in the uterus and in the process of uterine receptivity in a rat model. The results show that hypothyroidism impaired uterine receptivity by decreasing the level of E2 as well as decreasing the expression of the uterine-receptivity factors homeobox A10 and osteopontin. Moreover, hypothyroidism caused changes in the expression of elements of the prostaglandin E2, F, and I2 signaling pathways and changed the levels of those prostaglandins in the uterine tissue. The results suggest that the mechanisms by which hypothyroidism affects female reproductive abnormalities might involve the prostaglandin signaling pathway, resulting in a subsequent reduction in uterine receptivity. View Full-Text
Keywords: rat; hypothyroidism; reproduction; prostaglandins; uterine receptivity rat; hypothyroidism; reproduction; prostaglandins; uterine receptivity
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MDPI and ACS Style

Kowalczyk-Zieba, I.; Staszkiewicz-Chodor, J.; Boruszewska, D.; Lukaszuk, K.; Jaworska, J.; Woclawek-Potocka, I. Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling. Animals 2021, 11, 2636. https://doi.org/10.3390/ani11092636

AMA Style

Kowalczyk-Zieba I, Staszkiewicz-Chodor J, Boruszewska D, Lukaszuk K, Jaworska J, Woclawek-Potocka I. Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling. Animals. 2021; 11(9):2636. https://doi.org/10.3390/ani11092636

Chicago/Turabian Style

Kowalczyk-Zieba, Ilona, Joanna Staszkiewicz-Chodor, Dorota Boruszewska, Krzysztof Lukaszuk, Joanna Jaworska, and Izabela Woclawek-Potocka. 2021. "Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling" Animals 11, no. 9: 2636. https://doi.org/10.3390/ani11092636

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