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Article

SARS-CoV-2 Seroprevalence in Household Domestic Ferrets (Mustela putorius furo)

1
Menescalia Veterinary Clinic, 46020 Valencia, Spain
2
Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
3
Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
4
Departament of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
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Instituto Agroalimentario de Aragón-IA2, University of Zaragoza, 50009 Zaragoza, Spain
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Department of Animal Production and Sciences of the Food, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain
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Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, University of Zaragoza, 50009 Zaragoza, Spain
8
Aragon I+D Foundation (ARAID), 50018 Zaragoza, Spain
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Laboratorio de Microscopías Avanzada (LMA), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, 50018 Zaragoza, Spain
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Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, 1165 Copenhagen, Denmark
11
Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain
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Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, 50009 Zaragoza, Spain
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Infectious Disease Department, University Hospital Lozano Blesa, 50009 Zaragoza, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Jane M. Williams
Animals 2021, 11(3), 667; https://doi.org/10.3390/ani11030667
Received: 9 February 2021 / Revised: 22 February 2021 / Accepted: 25 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Impact of COVID-19 on Animal Management and Welfare)
Animal infections with SARS-CoV-2 have been reported in different countries and several animal species have been proven to be susceptible to infection with SARS-CoV-2 both naturally or by experimental infection. Moreover, infections under natural conditions in more than 20 mink farms have been reported where humans could have been the source of infection for minks. However, little information is available about the susceptibility of pet animals under natural conditions and currently there is no SARS-CoV-2 epidemiological assessment occurrence in household ferrets. In this study, the presence of SARS-CoV-2 antibodies was evaluated in serum samples obtained from 127 household ferrets (Mustela putorius furo) in the Province of Valencia (Spain). Two ferrets tested positive to SARS-CoV-2 (1.57%) by in-house enzyme-linked immunosorbent assay based on receptor binding domain (RBD) of Spike antigen. Furthermore, anti-RBD SARS-CoV-2 antibodies persisted at detectable levels in a seropositive SARS-CoV-2 domestic ferret beyond 129 days since the first-time antibodies were detected. This study reports for the first time the evidence of household pet ferrets exposure to SARS-CoV-2 in Spain to date.
Animal infections with SARS-CoV-2 have been reported in different countries and several animal species have been proven to be susceptible to infection with SARS-CoV-2 both naturally and by experimental infection. Moreover, infections under natural conditions in more than 20 mink farms have been reported where humans could have been the source of infection for minks. However, little information is available about the susceptibility of pet animals under natural conditions and currently there is no SARS-CoV-2 epidemiological assessment occurrence in household ferrets. In this study, the presence of SARS-CoV-2 antibodies was evaluated in serum samples obtained from 127 household ferrets (Mustela putorius furo) in the Province of Valencia (Spain). Two ferrets tested positive to SARS-CoV-2 (1.57%) by in-house enzyme-linked immunosorbent assay based on receptor binding domain (RBD) of Spike antigen. Furthermore, anti-RBD SARS-CoV-2 antibodies persisted at detectable levels in a seropositive SARS-CoV-2 domestic ferret beyond 129 days since the first time antibodies were detected. This study reports for the first time the evidence of household pet ferrets exposure to SARS-CoV-2 in Spain to date. View Full-Text
Keywords: coronavirus disease 2019 (COVID-19); household ferrets; ELISA; SARS-CoV-2; serology coronavirus disease 2019 (COVID-19); household ferrets; ELISA; SARS-CoV-2; serology
MDPI and ACS Style

Giner, J.; Villanueva-Saz, S.; Tobajas, A.P.; Pérez, M.D.; González, A.; Verde, M.; Yzuel, A.; García-García, A.; Taleb, V.; Lira-Navarrete, E.; Hurtado-Guerrero, R.; Pardo, J.; Santiago, L.; Paño, J.R.; Ruíz, H.; Lacasta, D.; Fernández, A. SARS-CoV-2 Seroprevalence in Household Domestic Ferrets (Mustela putorius furo). Animals 2021, 11, 667. https://doi.org/10.3390/ani11030667

AMA Style

Giner J, Villanueva-Saz S, Tobajas AP, Pérez MD, González A, Verde M, Yzuel A, García-García A, Taleb V, Lira-Navarrete E, Hurtado-Guerrero R, Pardo J, Santiago L, Paño JR, Ruíz H, Lacasta D, Fernández A. SARS-CoV-2 Seroprevalence in Household Domestic Ferrets (Mustela putorius furo). Animals. 2021; 11(3):667. https://doi.org/10.3390/ani11030667

Chicago/Turabian Style

Giner, Jacobo, Sergio Villanueva-Saz, Ana P. Tobajas, María D. Pérez, Ana González, Maite Verde, Andrés Yzuel, Ana García-García, Víctor Taleb, Erandi Lira-Navarrete, Ramón Hurtado-Guerrero, Julián Pardo, Llipsy Santiago, José R. Paño, Héctor Ruíz, Delia Lacasta, and Antonio Fernández. 2021. "SARS-CoV-2 Seroprevalence in Household Domestic Ferrets (Mustela putorius furo)" Animals 11, no. 3: 667. https://doi.org/10.3390/ani11030667

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