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Article

Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt

1
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
2
Faculty of Medicine, Assiut University, Assiut PO 7151, Egypt
3
Biology Department, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
4
College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Pazzani
Microorganisms 2021, 9(9), 1880; https://doi.org/10.3390/microorganisms9091880
Received: 23 August 2021 / Revised: 31 August 2021 / Accepted: 1 September 2021 / Published: 5 September 2021
(This article belongs to the Special Issue Antimicrobial Resistance and Genetic Elements in Bacteria)
Klebsiella pneumoniae is an important human pathogen in both developing and industrialised countries that can causes a variety of human infections, such as pneumonia, urinary tract infections and bacteremia. Like many Gram-negative bacteria, it is becoming resistant to many frontline antibiotics, such as carbapenem and cephalosporin antibiotics. In Egypt, K. pneumoniae is increasingly recognised as an emerging pathogen, with high levels of antibiotic resistance. However, few Egyptian K. pneumoniae strains have been sequenced and characterised. Hence, here, we present the genome sequence of a multidrug resistant K. pneumoniae strain, KPE16, which was isolated from a child in Assiut, Egypt. We report that it carries multiple antimicrobial resistance genes, including a blaNDM-1 carbapenemase and extended spectrum β-lactamase genes (i.e., blaSHV-40, blaTEM-1B, blaOXA-9 and blaCTX-M-15). By comparing this strain with other Egyptian isolates, we identified common plasmids, resistance genes and virulence determinants. Our analysis suggests that some of the resistance plasmids that we have identified are circulating in K. pneumoniae strains in Egypt, and are likely a source of antibiotic resistance throughout the world. View Full-Text
Keywords: Klebsiella pneumoniae; antibiotic resistance; virulence; whole genome sequencing Klebsiella pneumoniae; antibiotic resistance; virulence; whole genome sequencing
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MDPI and ACS Style

Abdelwahab, R.; Alhammadi, M.M.; Hassan, E.A.; Ahmed, E.H.; Abu-Faddan, N.H.; Daef, E.A.; Busby, S.J.W.; Browning, D.F. Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt. Microorganisms 2021, 9, 1880. https://doi.org/10.3390/microorganisms9091880

AMA Style

Abdelwahab R, Alhammadi MM, Hassan EA, Ahmed EH, Abu-Faddan NH, Daef EA, Busby SJW, Browning DF. Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt. Microorganisms. 2021; 9(9):1880. https://doi.org/10.3390/microorganisms9091880

Chicago/Turabian Style

Abdelwahab, Radwa, Munirah M. Alhammadi, Ehsan A. Hassan, Entsar H. Ahmed, Nagla H. Abu-Faddan, Enas A. Daef, Stephen J.W. Busby, and Douglas F. Browning. 2021. "Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt" Microorganisms 9, no. 9: 1880. https://doi.org/10.3390/microorganisms9091880

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