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Review

The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Deepak Shukla
Microorganisms 2021, 9(9), 1870; https://doi.org/10.3390/microorganisms9091870
Received: 15 July 2021 / Revised: 27 August 2021 / Accepted: 31 August 2021 / Published: 3 September 2021
(This article belongs to the Special Issue Cytomegalovirus, Inflammation and Oncomodulation)
Human herpesviruses (HHVs): herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), HHV-6, HHV-7, and HHV-8, are known to be part of a family of DNA viruses that cause several diseases in humans. In clinical practice of inflammatory bowel disease (IBD), the complication of CMV enterocolitis, which is caused by CMV reactivation under disruption of intestinal barrier function, inflammation, or strong immunosuppressive therapy, is well known to affect the prognosis of disease. However, the relationship between other HHVs and IBD remains unclear. In the transplantation field, reactivation of other viruses, such as HHV-6, could cause colitis under immunosuppressed condition. Recent research revealed that combined infection of some HHVs could be a risk factor for colectomy in patients with ulcerative colitis. This suggests that it would be important to clarify HHV behavior in the treatment for patients with IBD, especially in those under immunosuppressive therapies. Looking at the relationship with recently emerged novel coronaviruses (SARS-CoV-2), there are reports describe that SARS-CoV-2 might induce reactivation of HSV-1, EBV, VZV (herpes zoster), and HHV-6/7. If SARS-CoV-2 infection becomes common, vigilance against HHV reactivation may become more crucial. In this review, we discuss the impact of HHVs in clinical practice of inflammatory bowel diseases, especially during the SARS-CoV-2 pandemic. View Full-Text
Keywords: human herpesviruses; herpes simplex virus; varicella-zoster virus; Epstein-Barr virus; cytomegalovirus; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; SARS-CoV-2; COVID-19 human herpesviruses; herpes simplex virus; varicella-zoster virus; Epstein-Barr virus; cytomegalovirus; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; SARS-CoV-2; COVID-19
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MDPI and ACS Style

Hosomi, S.; Nishida, Y.; Fujiwara, Y. The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19. Microorganisms 2021, 9, 1870. https://doi.org/10.3390/microorganisms9091870

AMA Style

Hosomi S, Nishida Y, Fujiwara Y. The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19. Microorganisms. 2021; 9(9):1870. https://doi.org/10.3390/microorganisms9091870

Chicago/Turabian Style

Hosomi, Shuhei, Yu Nishida, and Yasuhiro Fujiwara. 2021. "The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19" Microorganisms 9, no. 9: 1870. https://doi.org/10.3390/microorganisms9091870

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