Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections
Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium
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Academic Editor: Valeria Cagno
Microorganisms 2021, 9(8), 1599; https://doi.org/10.3390/microorganisms9081599
Received: 22 June 2021
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Revised: 21 July 2021
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Accepted: 21 July 2021
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Published: 27 July 2021
(This article belongs to the Special Issue Antiviral Research)
Acute gastroenteritis caused by virus has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The main culprits are rotaviruses, noroviruses, sapoviruses, astroviruses, and enteric adenoviruses. Currently, there are no antiviral drugs available for the prevention or treatment of viral gastroenteritis. Here, we describe the antivirals that were identified as having in vitro and/or in vivo activity against these viruses, originating from in silico design or library screening, natural sources or being repurposed drugs. We also highlight recent advances in model systems available for this (hard to cultivate) group of viruses, such as organoid technologies, and that will facilitate antiviral studies as well as fill some of current knowledge gaps that hamper the development of highly efficient therapies against gastroenteric viruses.
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Keywords:
norovirus; rotavirus; sapovirus; adenovirus; astrovirus; viral gastroenteritis; in vitro; in vivo; enteroids
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MDPI and ACS Style
Santos-Ferreira, N.; Van Dycke, J.; Neyts, J.; Rocha-Pereira, J. Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections. Microorganisms 2021, 9, 1599. https://doi.org/10.3390/microorganisms9081599
AMA Style
Santos-Ferreira N, Van Dycke J, Neyts J, Rocha-Pereira J. Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections. Microorganisms. 2021; 9(8):1599. https://doi.org/10.3390/microorganisms9081599
Chicago/Turabian StyleSantos-Ferreira, Nanci, Jana Van Dycke, Johan Neyts, and Joana Rocha-Pereira. 2021. "Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections" Microorganisms 9, no. 8: 1599. https://doi.org/10.3390/microorganisms9081599
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