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Listeria monocytogenes Cold Shock Proteins: Small Proteins with A Huge Impact

Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland
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Academic Editor: Elena González-Fandos
Microorganisms 2021, 9(5), 1061; https://doi.org/10.3390/microorganisms9051061
Received: 24 April 2021 / Revised: 11 May 2021 / Accepted: 12 May 2021 / Published: 14 May 2021
(This article belongs to the Special Issue An Update on Listeria monocytogenes)
Listeria monocytogenes has evolved an extensive array of mechanisms for coping with stress and adapting to changing environmental conditions, ensuring its virulence phenotype expression. For this reason, L. monocytogenes has been identified as a significant food safety and public health concern. Among these adaptation systems are cold shock proteins (Csps), which facilitate rapid response to stress exposure. L. monocytogenes has three highly conserved csp genes, namely, cspA, cspB, and cspD. Using a series of csp deletion mutants, it has been shown that L. monocytogenes Csps are important for biofilm formation, motility, cold, osmotic, desiccation, and oxidative stress tolerance. Moreover, they are involved in overall virulence by impacting the expression of virulence-associated phenotypes, such as hemolysis and cell invasion. It is postulated that during stress exposure, Csps function to counteract harmful effects of stress, thereby preserving cell functions, such as DNA replication, transcription and translation, ensuring survival and growth of the cell. Interestingly, it seems that Csps might suppress tolerance to some stresses as their removal resulted in increased tolerance to stresses, such as desiccation for some strains. Differences in csp roles among strains from different genetic backgrounds are apparent for desiccation tolerance and biofilm production. Additionally, hierarchical trends for the different Csps and functional redundancies were observed on their influences on stress tolerance and virulence. Overall current data suggest that Csps have a wider role in bacteria physiology than previously assumed. View Full-Text
Keywords: cold shock protein; cold; osmotic; stress tolerance; virulence; biofilm; Listeria monocytogenes cold shock protein; cold; osmotic; stress tolerance; virulence; biofilm; Listeria monocytogenes
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MDPI and ACS Style

Muchaamba, F.; Stephan, R.; Tasara, T. Listeria monocytogenes Cold Shock Proteins: Small Proteins with A Huge Impact. Microorganisms 2021, 9, 1061. https://doi.org/10.3390/microorganisms9051061

AMA Style

Muchaamba F, Stephan R, Tasara T. Listeria monocytogenes Cold Shock Proteins: Small Proteins with A Huge Impact. Microorganisms. 2021; 9(5):1061. https://doi.org/10.3390/microorganisms9051061

Chicago/Turabian Style

Muchaamba, Francis, Roger Stephan, and Taurai Tasara. 2021. "Listeria monocytogenes Cold Shock Proteins: Small Proteins with A Huge Impact" Microorganisms 9, no. 5: 1061. https://doi.org/10.3390/microorganisms9051061

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