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Article

Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota

1
National Centre of Neurology and Psychiatry, Department of Mental Disorder Research, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, Kodaira-shi, Tokyo 187-8502, Japan
2
Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan
3
National Centre of Neurology and Psychiatry, Department of Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira-shi, Tokyo 187-8551, Japan
4
Department of Psychiatry, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Piotr B. Heczko
Microorganisms 2021, 9(5), 1026; https://doi.org/10.3390/microorganisms9051026
Received: 2 April 2021 / Revised: 4 May 2021 / Accepted: 6 May 2021 / Published: 10 May 2021
(This article belongs to the Special Issue An Update on Lactobacillus)
We previously reported lower counts of lactobacilli and Bifidobacterium in the gut microbiota of patients with major depressive disorder (MDD), compared with healthy controls. This prompted us to investigate the possible efficacy of a probiotic strain, Lacticaseibacillus paracasei strain Shirota (LcS; basonym, Lactobacillus casei strain Shirota; daily intake of 8.0 × 1010 colony-forming units), in alleviating depressive symptoms. A single-arm trial was conducted on 18 eligible patients with MDD or bipolar disorder (BD) (14 females and 4 males; 15 MDD and 3 BD), assessing changes in psychiatric symptoms, the gut microbiota, and biological markers for intestinal permeability and inflammation, over a 12-week intervention period. Depression severity, evaluated by the Hamilton Depression Rating Scale, was significantly alleviated after LcS treatment. The intervention-associated reduction of depressive symptoms was associated with the gut microbiota, and more pronounced when Bifidobacterium and the Atopobium clusters of the Actinobacteria phylum were maintained at higher counts. No significant changes were observed in the intestinal permeability or inflammation markers. Although it was difficult to estimate the extent of the effect of LcS treatment alone, the results indicated that it was beneficial to alleviate depressive symptoms, partly through its association with abundance of Actinobacteria in the gut microbiota. View Full-Text
Keywords: probiotic; major depressive disorder; bipolar disorder; gut microbiota; Actinobacteria probiotic; major depressive disorder; bipolar disorder; gut microbiota; Actinobacteria
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MDPI and ACS Style

Otaka, M.; Kikuchi-Hayakawa, H.; Ogura, J.; Ishikawa, H.; Yomogida, Y.; Ota, M.; Hidese, S.; Ishida, I.; Aida, M.; Matsuda, K.; Kawai, M.; Yoshida, S.; Kunugi, H. Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota. Microorganisms 2021, 9, 1026. https://doi.org/10.3390/microorganisms9051026

AMA Style

Otaka M, Kikuchi-Hayakawa H, Ogura J, Ishikawa H, Yomogida Y, Ota M, Hidese S, Ishida I, Aida M, Matsuda K, Kawai M, Yoshida S, Kunugi H. Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota. Microorganisms. 2021; 9(5):1026. https://doi.org/10.3390/microorganisms9051026

Chicago/Turabian Style

Otaka, Machiko, Hiroko Kikuchi-Hayakawa, Jun Ogura, Hiroshi Ishikawa, Yukihito Yomogida, Miho Ota, Shinsuke Hidese, Ikki Ishida, Masanori Aida, Kazunori Matsuda, Mitsuhisa Kawai, Sumiko Yoshida, and Hiroshi Kunugi. 2021. "Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota" Microorganisms 9, no. 5: 1026. https://doi.org/10.3390/microorganisms9051026

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