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Article

Atrial Natriuretic Peptide Affects Skin Commensal Staphylococcus epidermidis and Cutibacterium acnes Dual-Species Biofilms

1
Laboratory of Viability of Microorganisms, Federal Research Center “Fundamentals of Biotechnology” of Russian Academy of Sciences, 117312 Moscow, Russia
2
Department of Bioengineering, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia
3
Laboratory of Microbiology of Anthropogenic Habitats, Federal Research Center “Fundamentals of Biotechnology” of Russian Academy of Sciences, 117312 Moscow, Russia
4
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Ilana Kolodkin-Gal
Microorganisms 2021, 9(3), 552; https://doi.org/10.3390/microorganisms9030552
Received: 14 February 2021 / Revised: 4 March 2021 / Accepted: 4 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Host–Biofilm Interactions)
The first evidence of the atrial natriuretic peptide (ANP) effect on mono-species and dual-species biofilms of skin commensals Cutibacterium acnes and Staphylococcus epidermidis was obtained in different model systems. Elucidation of the mechanism of action of hormones on the microbial communities of human skin is an important physiological and medical aspect. Under anaerobic conditions, ANP at a concentration of 6.5 × 10−10 M inhibits the growth of S. epidermidis biofilms and stimulates the growth of C. acnes biofilms, and a lesser effect has been demonstrated on planktonic cultures. In biofilms, ANP stimulates aggregation in C. acnes and aggregate dispersion of S. epidermidis, while in S. epidermidis, ANP also stimulates the metabolic activity of cells. Analysis of dual-species biofilms has shown the dominance of S. epidermidis, while ANP increases the ratio of C. acnes biomass in the community. ANP decreases the growth rate of S. epidermidis biofilms and increases that of C. acnes. The effect of ANP is not dependent on the surface type and probably affects other targets in microbial cells. Thus, the potential regulatory effect of human ANP on skin microbe dual-species communities has been shown, and its potential has been demonstrated to change microbiota homeostasis on the skin. View Full-Text
Keywords: biofilms; dual-species biofilms; atrial natriuretic peptide; hormones; skin microbiota; Staphylococcus epidermidis; Cutibacterium acnes biofilms; dual-species biofilms; atrial natriuretic peptide; hormones; skin microbiota; Staphylococcus epidermidis; Cutibacterium acnes
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MDPI and ACS Style

Ovcharova, M.A.; Geraskina, O.V.; Danilova, N.D.; Botchkova, E.A.; Martyanov, S.V.; Feofanov, A.V.; Plakunov, V.K.; Gannesen, A.V. Atrial Natriuretic Peptide Affects Skin Commensal Staphylococcus epidermidis and Cutibacterium acnes Dual-Species Biofilms. Microorganisms 2021, 9, 552. https://doi.org/10.3390/microorganisms9030552

AMA Style

Ovcharova MA, Geraskina OV, Danilova ND, Botchkova EA, Martyanov SV, Feofanov AV, Plakunov VK, Gannesen AV. Atrial Natriuretic Peptide Affects Skin Commensal Staphylococcus epidermidis and Cutibacterium acnes Dual-Species Biofilms. Microorganisms. 2021; 9(3):552. https://doi.org/10.3390/microorganisms9030552

Chicago/Turabian Style

Ovcharova, Maria A., Olga V. Geraskina, Natalya D. Danilova, Ekaterina A. Botchkova, Sergey V. Martyanov, Alexey V. Feofanov, Vladimir K. Plakunov, and Andrei V. Gannesen 2021. "Atrial Natriuretic Peptide Affects Skin Commensal Staphylococcus epidermidis and Cutibacterium acnes Dual-Species Biofilms" Microorganisms 9, no. 3: 552. https://doi.org/10.3390/microorganisms9030552

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