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Article

Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome

1
Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43201 Reus, Spain
2
Institut D’Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari de Sant Joan de Reus, 43204 Reus, Spain
3
CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain
5
Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL-UMH, 03010 Alicante, Spain
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CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
7
Department of Preventive Medicine, University of Valencia, 46100 Valencia, Spain
8
Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Research Institute (IMIM), 08003 Barcelona, Spain
9
Endocrinology and Nutrition Department, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic Universitari, 08036 Barcelona, Spain
10
CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
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Department of Preventive Medicine and Public Health, University of Navarra, IdiSNA, 31008 Pamplona, Spain
12
Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA
*
Authors to whom correspondence should be addressed.
Senior authors.
Academic Editor: Mar Larrosa
Microorganisms 2021, 9(2), 346; https://doi.org/10.3390/microorganisms9020346
Received: 12 January 2021 / Revised: 4 February 2021 / Accepted: 6 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue The Human Gut Microbiome, Diets and Health)
Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55–75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation. View Full-Text
Keywords: obesity; gut microbiota; BMI; weight loss; 16S sequencing; clinical trial obesity; gut microbiota; BMI; weight loss; 16S sequencing; clinical trial
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MDPI and ACS Style

Atzeni, A.; Galié, S.; Muralidharan, J.; Babio, N.; Tinahones, F.J.; Vioque, J.; Corella, D.; Castañer, O.; Vidal, J.; Moreno-Indias, I.; Torres-Collado, L.; Fernández-Carrión, R.; Fitó, M.; Olbeyra, R.; Martínez-González, M.A.; Bulló, M.; Salas-Salvadó, J. Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome. Microorganisms 2021, 9, 346. https://doi.org/10.3390/microorganisms9020346

AMA Style

Atzeni A, Galié S, Muralidharan J, Babio N, Tinahones FJ, Vioque J, Corella D, Castañer O, Vidal J, Moreno-Indias I, Torres-Collado L, Fernández-Carrión R, Fitó M, Olbeyra R, Martínez-González MA, Bulló M, Salas-Salvadó J. Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome. Microorganisms. 2021; 9(2):346. https://doi.org/10.3390/microorganisms9020346

Chicago/Turabian Style

Atzeni, Alessandro, Serena Galié, Jananee Muralidharan, Nancy Babio, Francisco José Tinahones, Jesús Vioque, Dolores Corella, Olga Castañer, Josep Vidal, Isabel Moreno-Indias, Laura Torres-Collado, Rebeca Fernández-Carrión, Montserrat Fitó, Romina Olbeyra, Miguel Angel Martínez-González, Monica Bulló, and Jordi Salas-Salvadó. 2021. "Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome" Microorganisms 9, no. 2: 346. https://doi.org/10.3390/microorganisms9020346

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