Next Article in Journal
Probiotic Potential and Technological Properties of Bacteriocinogenic Lactococcus lactis Subsp. Lactis UTNGt28 from a Native Amazonian Fruit as a Yogurt Starter Culture
Previous Article in Journal
Nasal Microbiota in RSV Bronchiolitis
Article

The Role of Gene Elongation in the Evolution of Histidine Biosynthetic Genes

Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(5), 732; https://doi.org/10.3390/microorganisms8050732
Received: 7 April 2020 / Revised: 7 May 2020 / Accepted: 11 May 2020 / Published: 13 May 2020
(This article belongs to the Section Molecular Microbiology and Immunology)
Gene elongation is a molecular mechanism consisting of an in-tandem duplication of a gene and divergence and fusion of the two copies, resulting in a gene constituted by two divergent paralogous modules. The aim of this work was to evaluate the importance of gene elongation in the evolution of histidine biosynthetic genes and to propose a possible evolutionary model for some of them. Concerning the genes hisA and hisF, which code for two homologous (β/α)8-barrels, it has been proposed that the two extant genes could be the result of a cascade of gene elongation/domain shuffling events starting from an ancestor gene coding for just one (β/α) module. A gene elongation event has also been proposed for the evolution of hisB and hisD; structural analyses revealed the possibility of an early elongation event, resulting in the repetition of modules. Furthermore, it is quite possible that the gene elongations responsible for the evolution of the four proteins occurred before the earliest phylogenetic divergence. In conclusion, gene elongation events seem to have played a crucial role in the evolution of the histidine biosynthetic pathway, and they may have shaped the structures of many genes during the first steps of their evolution. View Full-Text
Keywords: gene elongation; histidine biosynthesis; patchwork hypothesis gene elongation; histidine biosynthesis; patchwork hypothesis
Show Figures

Figure 1

MDPI and ACS Style

Del Duca, S.; Chioccioli, S.; Vassallo, A.; Castronovo, L.M.; Fani, R. The Role of Gene Elongation in the Evolution of Histidine Biosynthetic Genes. Microorganisms 2020, 8, 732. https://doi.org/10.3390/microorganisms8050732

AMA Style

Del Duca S, Chioccioli S, Vassallo A, Castronovo LM, Fani R. The Role of Gene Elongation in the Evolution of Histidine Biosynthetic Genes. Microorganisms. 2020; 8(5):732. https://doi.org/10.3390/microorganisms8050732

Chicago/Turabian Style

Del Duca, Sara, Sofia Chioccioli, Alberto Vassallo, Lara M. Castronovo, and Renato Fani. 2020. "The Role of Gene Elongation in the Evolution of Histidine Biosynthetic Genes" Microorganisms 8, no. 5: 732. https://doi.org/10.3390/microorganisms8050732

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop