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The Controversial Role of Human Gut Lachnospiraceae

Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, Italy
Clinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70121 Bari, Italy
Faculty of Science and Technology, Free University of Bozen, 39100 Bolzano, Italy
Authors to whom correspondence should be addressed.
Microorganisms 2020, 8(4), 573;
Received: 27 February 2020 / Revised: 5 April 2020 / Accepted: 13 April 2020 / Published: 15 April 2020
(This article belongs to the Section Gut Microbiota)
The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology. View Full-Text
Keywords: Lachnospiraceae; gut microbiota; gut microbial pathways; gut microbial metabolites; health; disease Lachnospiraceae; gut microbiota; gut microbial pathways; gut microbial metabolites; health; disease
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MDPI and ACS Style

Vacca, M.; Celano, G.; Calabrese, F.M.; Portincasa, P.; Gobbetti, M.; De Angelis, M. The Controversial Role of Human Gut Lachnospiraceae. Microorganisms 2020, 8, 573.

AMA Style

Vacca M, Celano G, Calabrese FM, Portincasa P, Gobbetti M, De Angelis M. The Controversial Role of Human Gut Lachnospiraceae. Microorganisms. 2020; 8(4):573.

Chicago/Turabian Style

Vacca, Mirco, Giuseppe Celano, Francesco M. Calabrese, Piero Portincasa, Marco Gobbetti, and Maria De Angelis. 2020. "The Controversial Role of Human Gut Lachnospiraceae" Microorganisms 8, no. 4: 573.

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