Next Article in Journal
Proteomic Adaptation of Streptococcus pneumoniae to the Human Antimicrobial Peptide LL-37
Next Article in Special Issue
The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection
Previous Article in Journal
Ivermectin Inhibits Bovine Herpesvirus 1 DNA Polymerase Nuclear Import and Interferes With Viral Replication
Previous Article in Special Issue
Effects of a Diet Supplemented with Exogenous Catalase from Penicillium notatum on Intestinal Development and Microbiota in Weaned Piglets
Open AccessArticle

Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment

1
School of Public Health, Lanzhou University, No. 222 TianshuiNanlu, Lanzhou 730000, China
2
Mengzi Center for Disease Prevention and Control, Mengzi 661199, China
*
Authors to whom correspondence should be addressed.
Microorganisms 2020, 8(3), 411; https://doi.org/10.3390/microorganisms8030411
Received: 30 January 2020 / Revised: 1 March 2020 / Accepted: 11 March 2020 / Published: 13 March 2020
(This article belongs to the Special Issue Host-Gut Microbiota Interactions)
In this work, we investigate differences in gut microbial diversity driven by drug use or by the widely used methods for drug cessation: methadone maintenance treatment (MMT) and compulsory detention (CD). Methods: 99 participants (28 CD participants, 16 MMT patients, 27 drug users, and 28 healthy controls) were selected using strict inclusion criteria. Nutritional intake and gut microbial diversity were analyzed with bioinformatics tools and SPSS 20.0. Results: Alpha diversity was not significantly different among groups, whereas beta diversity of gut microbiota and nutrient intake were significantly higher among MMT patients. Taxa were unevenly distributed between groups, with drug users having the highest proportion of Ruminococcus and MMT patients having the highest abundance of Bifidobacterium and Lactobacillus. Conclusion: Drug use, cessation method, and diet contribute to shaping human gut communities. High beta diversity among MMT patients is likely driven by methadone use and high nutrient intake, leading to increased orexin A and enrichment for beneficial bacteria, while diversity in CD participants is largely influenced by diet. View Full-Text
Keywords: gut microbial diversity; human gut microbiota; compulsory detention participants; MMT patients; drug users; drug cessation; 16S rRNA gene gut microbial diversity; human gut microbiota; compulsory detention participants; MMT patients; drug users; drug cessation; 16S rRNA gene
Show Figures

Graphical abstract

MDPI and ACS Style

Li, Q.; Chen, S.; Liu, K.; Long, D.; Liu, D.; Jing, Z.; Huang, X. Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment. Microorganisms 2020, 8, 411.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop