Next Article in Journal
Human Herpesvirus 8 and Host-Cell Interaction: Long-Lasting Physiological Modifications, Inflammation and Related Chronic Diseases
Next Article in Special Issue
Investigation of Heterologously Expressed Glucose-6-Phosphate Dehydrogenase Genes in a Yeast zwf1 Deletion
Previous Article in Journal
Distinct Roles of Acidophiles in Complete Oxidation of High-Sulfur Ferric Leach Product of Zinc Sulfide Concentrate
Previous Article in Special Issue
Digestive Ability, Physiological Characteristics, and Rumen Bacterial Community of Holstein Finishing Steers in Response to Three Nutrient Density Diets as Fattening Phases Advanced
Open AccessArticle

A Novel Lactic Acid Bacteria Mixture: Macrophage-Targeted Prophylactic Intervention in Colorectal Cancer Management

1
Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, Srobarova 2, 041 54 Kosice, Slovak
2
School of Biological and Marine Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
3
School of Biomedical Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
*
Author to whom correspondence should be addressed.
Shared senior authors.
Microorganisms 2020, 8(3), 387; https://doi.org/10.3390/microorganisms8030387
Received: 17 January 2020 / Revised: 25 February 2020 / Accepted: 10 March 2020 / Published: 11 March 2020
(This article belongs to the Special Issue Recent Advances in Applied Microbiology)
Colorectal cancer (CRC) is one of the most common forms of cancer. Its onset from chronic inflammation is widely accepted. Moreover, dysbiosis plays an undeniable role, thus the use of probiotics in CRC has been suggested. They exhibit both anti- and pro-inflammatory properties and restore balance in the microbiota. The aim of this study was to investigate the immunomodulatory properties of six lactobacilli with probiotic features in an in vitro model of macrophage-like cells and to test these pooled probiotics for their anti-tumour properties in a chemically induced CRC model using Wistar male rats. Upon co-culture of M1- and M2-like macrophages with lactobacilli, cytokine release (TNF-α, IL-1β, IL-18, IL-23) and phagocytic activity using fluorescent-labelled bacteria were tested. The effects of orally administered probiotics on basic cancer and immune parameters and cytokine concentration (TNF-α, IL-1β, IL-18) in colon tumours were studied. Tested lactobacilli exhibited both pro- and anti-inflammatory properties in in vitro conditions. In vivo study showed that the administration of probiotics was able to decrease multiplicity, volume and total tumour numbers, restore colon length (p < 0.05) and increase IL-18 production (p < 0.05) in tumour tissue. These data indicate both an immunomodulatory effect of probiotics on distinct macrophage subsets and a protective effect against chemically-induced CRC. View Full-Text
Keywords: Lactobacillus salivarius; Lactobacillus plantarum; cytokines; immunomodulation; Wistar rat; 1,2-dimethylhydrazine Lactobacillus salivarius; Lactobacillus plantarum; cytokines; immunomodulation; Wistar rat; 1,2-dimethylhydrazine
Show Figures

Figure 1

MDPI and ACS Style

Hradicka, P.; Beal, J.; Kassayova, M.; Foey, A.; Demeckova, V. A Novel Lactic Acid Bacteria Mixture: Macrophage-Targeted Prophylactic Intervention in Colorectal Cancer Management. Microorganisms 2020, 8, 387. https://doi.org/10.3390/microorganisms8030387

AMA Style

Hradicka P, Beal J, Kassayova M, Foey A, Demeckova V. A Novel Lactic Acid Bacteria Mixture: Macrophage-Targeted Prophylactic Intervention in Colorectal Cancer Management. Microorganisms. 2020; 8(3):387. https://doi.org/10.3390/microorganisms8030387

Chicago/Turabian Style

Hradicka, Petra; Beal, Jane; Kassayova, Monika; Foey, Andrew; Demeckova, Vlasta. 2020. "A Novel Lactic Acid Bacteria Mixture: Macrophage-Targeted Prophylactic Intervention in Colorectal Cancer Management" Microorganisms 8, no. 3: 387. https://doi.org/10.3390/microorganisms8030387

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop