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Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective

Department of Public Health and Infectious Diseases, Section of Microbiology, University of Rome “Sapienza”, 00185 Rome, Italy
Cardiology, Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(5), 140;
Received: 15 April 2019 / Revised: 7 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Chlamydiae and Chlamydia like Bacteria)
PDF [535 KB, uploaded 16 May 2019]


Research in Chlamydia trachomatis and Chlamydia pneumoniae has gained new traction due to recent advances in molecular biology, namely the widespread use of the metagenomic analysis and the development of a stable genomic transformation system, resulting in a better understanding of Chlamydia pathogenesis. C. trachomatis, the leading cause of bacterial sexually transmitted diseases, is responsible of cervicitis and urethritis, and C. pneumoniae, a widespread respiratory pathogen, has long been associated with several chronic inflammatory diseases with great impact on public health. The present review summarizes the current evidence regarding the complex interplay between C. trachomatis and host defense factors in the genital micro-environment as well as the key findings in chronic inflammatory diseases associated to C. pneumoniae. View Full-Text
Keywords: Chlamydia trachomatis; Chlamydia pneumoniae; host-pathogen interaction Chlamydia trachomatis; Chlamydia pneumoniae; host-pathogen interaction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Di Pietro, M.; Filardo, S.; Romano, S.; Sessa, R. Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective. Microorganisms 2019, 7, 140.

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