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Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

Populations Virales et Pathogenèse, Institut Pasteur, CNRS UMR 3569, 75015 Paris, France
Ecole doctorale BioSPC, Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(5), 133;
Received: 24 April 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Emerging Vector Borne Infections: A Novel Threat for Global Health)
PDF [862 KB, uploaded 28 May 2019]


Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it was responsible for two worldwide epidemics with millions of cases in the last 15 years. However, other arthritogenic alphaviruses that are as of yet restrained to specific territories are the cause of neglected tropical diseases: O’nyong’nyong virus in Sub-Saharan Africa, Mayaro virus in Latin America, and Ross River virus in Australia and the Pacific island countries and territories. This review evaluates their emerging potential in light of the current knowledge for each of them and in comparison to chikungunya virus. View Full-Text
Keywords: alphaviruses; chikungunya virus; Mayaro virus; O’nyong’nyong virus; Ross River virus alphaviruses; chikungunya virus; Mayaro virus; O’nyong’nyong virus; Ross River virus

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Levi, L.I.; Vignuzzi, M. Arthritogenic Alphaviruses: A Worldwide Emerging Threat? Microorganisms 2019, 7, 133.

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