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Open AccessArticle

Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates

1
Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana, Slovenia
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MicroArctic Research Group, Dr. Brill + Partner GmbH Institut für Hygiene und Mikrobiologie, Stiegstück 34, 22339 Hamburg, Germany
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Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia
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Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(12), 600; https://doi.org/10.3390/microorganisms7120600
Received: 24 October 2019 / Revised: 19 November 2019 / Accepted: 20 November 2019 / Published: 22 November 2019
(This article belongs to the Section Environmental Microbiology)
Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vital ecosystem roles of decomposers as well as obligate or facultative symbionts of many other organisms. Due to their dispersal capabilities, microorganisms from cryosphere samples can be distributed around the world. Such dispersal involves both species with undefined pathogenicity and potentially pathogenic strains. Here we describe the isolation of fungal species from pristine Arctic locations in Greenland and Svalbard and the testing of the expression of characteristics usually associated with pathogenic species, such as growth at 37 °C, hemolytic ability, and susceptibility to antifungal agents. A total of 320 fungal isolates were obtained, and 24 of the most abundant and representative species were further analyzed. Species known as emerging pathogens, like Aureobasidium melanogenum, Naganishia albida, and Rhodotorula mucilaginosa, were able to grow at 37 °C, showed beta-hemolytic activity, and were intrinsically resistant to commonly used antifungals such as azoles and echinocandins. Antifungal resistance screening revealed a low susceptibility to voriconazole in N. albida and Penicillium spp. and to fluconazole in Glaciozyma watsonii and Glaciozyma-related taxon. View Full-Text
Keywords: Arctic; fungi; emerging pathogens; thermotolerance; hemolysis; antifungal resistance Arctic; fungi; emerging pathogens; thermotolerance; hemolysis; antifungal resistance
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Perini, L.; Mogrovejo, D.C.; Tomazin, R.; Gostinčar, C.; Brill, F.H.H.; Gunde-Cimerman, N. Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates. Microorganisms 2019, 7, 600.

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