Next Article in Journal
Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives
Next Article in Special Issue
Evaluation of Antimicrobial, Enzyme Inhibitory, Antioxidant and Cytotoxic Activities of Partially Purified Volatile Metabolites of Marine Streptomyces sp.S2A
Previous Article in Journal
Development of Versatile Vectors for Heterologous Expression in Bacillus
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview

Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes

Gause Institute of New Antibiotics, Bolshaya Pirogovskaya 11, 119021 Moscow, Russia
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
Author to whom correspondence should be addressed.
Microorganisms 2018, 6(2), 52;
Received: 2 May 2018 / Revised: 4 June 2018 / Accepted: 6 June 2018 / Published: 8 June 2018
PDF [1344 KB, uploaded 8 June 2018]


Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain “silent” under standard cultivation conditions. Some small molecules—chemical elicitors—can be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a brief account of the basic principles of the search for regulators of this type and their application. View Full-Text
Keywords: actinomycetes; antibiotic biosynthesis; silent biosynthetic pathways; γ-butyrolactones; HiTES; translation inhibitors actinomycetes; antibiotic biosynthesis; silent biosynthetic pathways; γ-butyrolactones; HiTES; translation inhibitors

Chart 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tyurin, A.P.; Alferova, V.A.; Korshun, V.A. Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes. Microorganisms 2018, 6, 52.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top