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Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes

1
Gause Institute of New Antibiotics, Bolshaya Pirogovskaya 11, 119021 Moscow, Russia
2
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Microorganisms 2018, 6(2), 52; https://doi.org/10.3390/microorganisms6020052
Received: 2 May 2018 / Revised: 4 June 2018 / Accepted: 6 June 2018 / Published: 8 June 2018
Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain “silent” under standard cultivation conditions. Some small molecules—chemical elicitors—can be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a brief account of the basic principles of the search for regulators of this type and their application. View Full-Text
Keywords: actinomycetes; antibiotic biosynthesis; silent biosynthetic pathways; γ-butyrolactones; HiTES; translation inhibitors actinomycetes; antibiotic biosynthesis; silent biosynthetic pathways; γ-butyrolactones; HiTES; translation inhibitors
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MDPI and ACS Style

Tyurin, A.P.; Alferova, V.A.; Korshun, V.A. Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes. Microorganisms 2018, 6, 52. https://doi.org/10.3390/microorganisms6020052

AMA Style

Tyurin AP, Alferova VA, Korshun VA. Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes. Microorganisms. 2018; 6(2):52. https://doi.org/10.3390/microorganisms6020052

Chicago/Turabian Style

Tyurin, Anton P., Vera A. Alferova, and Vladimir A. Korshun 2018. "Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes" Microorganisms 6, no. 2: 52. https://doi.org/10.3390/microorganisms6020052

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