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Microorganisms
Volume 13
Issue 9
10.3390/microorganisms13092028
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Characterization of Prophages and Their Genetic Cargo in Clinical M. abscessus Isolates

by
Sichun Luan
,
Yu Chen
,
Na Li
,
Qing Miao
,
Jue Pan
and
Bijie Hu
*
Department of Infectious Diseases, Zhongshan Hospital, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
Microorganisms 2025, 13(9), 2028; https://doi.org/10.3390/microorganisms13092028 (registering DOI)
Submission received: 21 July 2025 / Revised: 18 August 2025 / Accepted: 29 August 2025 / Published: 30 August 2025
(This article belongs to the Section Molecular Microbiology and Immunology)
Review Reports Versions Notes

Abstract

Limited data exist regarding lysogenic phages carried by M. abscessus, as well as regarding their roles played in diseases. Strains identified as M. abscessus from patients were collected. Prophages, virulence factors, and antibiotic resistance genes present in genomes were predicted, and correlations between prophages, virulence factors, antibiotic resistance genes, and clinical patient prognoses were analyzed. A total of 145 prophage sequences were detected in 56 M. abscessus strains. Prophages contained more virulence factors and antibiotic resistance genes, compared to known mycobacteriophages. The average sequence similarity among prophage sequences from a single patient was significantly higher than that among prophages from different patients or between prophages and known phages. The study showed that M. abscessus commonly carries prophages, which are enriched in virulence factors and antibiotic resistance genes relative to known phages, but their relationship to clinical prognoses requires further study. Prophages present in strains from different patients were highly diverse and exhibited low similarity with known mycobacterial phages.
Keywords: Mycobacterium abscessus; prophage; genome sequencing Mycobacterium abscessus; prophage; genome sequencing

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MDPI and ACS Style

Luan, S.; Chen, Y.; Li, N.; Miao, Q.; Pan, J.; Hu, B. Characterization of Prophages and Their Genetic Cargo in Clinical M. abscessus Isolates. Microorganisms 2025, 13, 2028. https://doi.org/10.3390/microorganisms13092028

AMA Style

Luan S, Chen Y, Li N, Miao Q, Pan J, Hu B. Characterization of Prophages and Their Genetic Cargo in Clinical M. abscessus Isolates. Microorganisms. 2025; 13(9):2028. https://doi.org/10.3390/microorganisms13092028

Chicago/Turabian Style

Luan, Sichun, Yu Chen, Na Li, Qing Miao, Jue Pan, and Bijie Hu. 2025. "Characterization of Prophages and Their Genetic Cargo in Clinical M. abscessus Isolates" Microorganisms 13, no. 9: 2028. https://doi.org/10.3390/microorganisms13092028

APA Style

Luan, S., Chen, Y., Li, N., Miao, Q., Pan, J., & Hu, B. (2025). Characterization of Prophages and Their Genetic Cargo in Clinical M. abscessus Isolates. Microorganisms, 13(9), 2028. https://doi.org/10.3390/microorganisms13092028

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