Co-Circulation of SARS-CoV-2 and Other Respiratory Pathogens in Upper and Lower Respiratory Tracts during Influenza Season 2022–2023 in Lazio Region
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Sample Collection
2.2. Molecular Assays
2.3. Statistical Evaluation
2.4. Culture
3. Results and Discussion
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total | SARS-CoV-2 Positive Other Respiratory Pathogens Positive | SARS-CoV-2 Negative Other Respiratory Pathogens Positive | SARS-CoV-2 Positive Other Respiratory Pathogens Negative | |||||
---|---|---|---|---|---|---|---|---|
NPS | BAL | NPS | BAL | NPS | BAL | NPS | BAL | |
Number of patients (%) | 306 (80.31) | 75 (19.67) | 9 (2.36) | 14 (3.67) | 193 (50.66) | 57 (14.96) | 104 (27.30) | 4 (1.05) |
Male (%) | 173 (56.54) | 44 (58.67) | 4 (44.44) | 10 (71.43) | 103 (53.37) | 33 (57.89) | 66 (63.46) | 1 (25.00) |
Female (%) | 133 (43.46) | 31 (41.33) | 5 (55.56) | 4 (28.57) | 90 (46.63) | 24 (42.11) | 38 (36.54) | 3 (75.00) |
Median age (years) (±SD) | 71 (±19.7) | 66 (±17.8) | 71 (±20.7) | 76.5 (±15.1) | 67 (±21.9) | 63 (±18.2) | 74.5 (±13.9) | 70.5 (±10.6) |
NPS | BAL | |
---|---|---|
Renal failure | 0.8 | - |
Respiratory failure | 0.8 | - |
Cerebral ischemia | 0.8 | - |
Cytomegalic disease | 0.8 | - |
Alveolar and parietoalveolar pneumopathies | 0.8 | - |
Severe sepsis | 0.8 | - |
Pleural effusion | 0.8 | - |
Complications of liver transplantation | 1.7 | - |
Influenza | 1.7 | - |
Meningitis | 2.5 | - |
HIV-1 complications | 5.0 | - |
Bacterial pneumonia | 5.0 | 6.7 |
Viral pneumonia | 5.9 | - |
Suspected tuberculosis | 5.9 | 6.7 |
COVID-19 pneumonia | 24.2 | - |
COVID-19 respiratory distress syndrome | 42.5 | 86.6 |
Pathogens | Percentage | |||
---|---|---|---|---|
NPS (SARS-CoV-2 Negative) | NPS (SARS-CoV-2 Positive) | BAL (SARS-CoV-2 Negative) | BAL (SARS-CoV-2 Positive) | |
Influenza A/B | 29.53% | 11.11% | 10.67% | - |
Parainfluenza Virus | 5.18% | - | 4.00% | - |
RSV | 26.42% | 11.11% | 5.33% | - |
Rhino/Entero | 23.32% | 44.44% | 6.67% | - |
Metapneumo Virus | 13.99% | 22.22% | 4.00% | - |
Adenovirus | 2.59% | - | 4.00% | - |
Coronavirus (non-SARS-CoV-2) | 4.66% | 33.33% | 2.67% | - |
B. pertussis | 1.55% | - | - | - |
A. baumannii complex | - | - | 1.33% | - |
P. aeruginosa | - | - | 22.67% | 35.71% |
Proteus spp. | - | - | 5.33% | 14.28% |
K. oxytoca | - | - | 5.33% | 7.14% |
K. pneumoniae group | - | - | 9.33% | 14.28% |
E. cloacae complex | - | - | 4.00% | - |
E. coli | - | - | 6.67% | 7.14% |
S. aureus | - | - | 21.33% | 21.43% |
H. influenzae | - | - | 9.33% | 14.28% |
S. pneumoniae | - | - | 2.67% | 7.14% |
L. pneumophila | - | - | 1.33% | - |
K. aerogenes | - | - | 1.33% | - |
S. marcescens | - | - | 2.67% | - |
S. pyogenes | - | - | 1.33% | - |
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Bordi, L.; Vulcano, A.; Sberna, G.; Nonis, M.; Giacomini, P.; Maggi, F.; Fontana, C.; Lalle, E. Co-Circulation of SARS-CoV-2 and Other Respiratory Pathogens in Upper and Lower Respiratory Tracts during Influenza Season 2022–2023 in Lazio Region. Microorganisms 2023, 11, 2239. https://doi.org/10.3390/microorganisms11092239
Bordi L, Vulcano A, Sberna G, Nonis M, Giacomini P, Maggi F, Fontana C, Lalle E. Co-Circulation of SARS-CoV-2 and Other Respiratory Pathogens in Upper and Lower Respiratory Tracts during Influenza Season 2022–2023 in Lazio Region. Microorganisms. 2023; 11(9):2239. https://doi.org/10.3390/microorganisms11092239
Chicago/Turabian StyleBordi, Licia, Antonella Vulcano, Giuseppe Sberna, Marino Nonis, Paolo Giacomini, Fabrizio Maggi, Carla Fontana, and Eleonora Lalle. 2023. "Co-Circulation of SARS-CoV-2 and Other Respiratory Pathogens in Upper and Lower Respiratory Tracts during Influenza Season 2022–2023 in Lazio Region" Microorganisms 11, no. 9: 2239. https://doi.org/10.3390/microorganisms11092239