Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Kingella kangas
3.2. Comparing Data between K. kingae and Pyogenic SA
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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TOTAL N = 75 | K. kingae N = 44 | Typical Pathogens N = 31 | p | |
---|---|---|---|---|
Age, months, median (IQR) | 16.8 (12–24) | 15.3 (12–24) | 18 (9.6–36) | 0.623 |
Age < 36 months, n (%) | 64 (85.3) | 41 (93.2) | 23 (74.2) | 0.043 |
Male gender, n (%) | 52 (69.3) | 32 (72.7) | 20 (64.5) | 0.448 |
Symptom duration at admission, days, median (IQR) | 3 (2–5) | 3 (2–5) | 2 (1–6) | 0.220 |
Fever duration, n (%) | 0.5 (0–2) | 0 (0–2) | 2 (0.75–7.5) | <0.001 |
Fever at admission, n (%) | 42/74 (56.8) | 16/43 (37.2) | 26 (83.9) | <0.001 |
Fever > 48 h of antibiotics, n (%) | 7/64 (10.9) | 0 (0) | 7/23 (30.4) | <0.001 |
Septic look, n (%) | 6/71(8.4) | 0 (0) | 6/28 (21.4) | 0.003 |
Osteoarthritis, n (%) | 10 (13.3) | 4 (9.1) | 6 (19.4) | 0.3 |
Disseminated infection, n (%) | 3 (4) | 0 (0) | 3 (9.6) | 0.067 |
Abscesses, n (%) | 3 (4) | 1 (2.3) | 2 (6.5) | 0.566 |
Myositis, n (%) | 10/73 (13.7) | 4/43 (9.3) | 6/30 (20) | 0.3 |
WBC count, cells/mm3, median (IQR) | 13,900 (10,800–18,200) | 12,700 (10,300–17,100) | 15,200 (11,300–19,700) | 0.58 |
WBC < 14,000/mm3, n (%) | 38/71 (53.5) | 24/40 (60) | 14 (41.9) | 0.214 |
Platelet’s count, cells/mm3, median (IQR) | 505,000 (363,000–571,100) | 474,500 (376,000–530,500) | 554,000 (346,000 690,000) | 0.133 |
CRP peak, mg/L, median (IQR) | 61.6 (30–147) | 40.5 (18–69) | 162 (93.7–215) | <0.001 |
CRP < 100, mg/L, n (%) | 47 (62.7) | 39 (88.6) | 8 (25.8) | <0.001 |
CRP at 48–96 h, median (IQR) | 27.4 (9.7–79) | 16.3 (5–29) | 73.3 (30–150) | <0.001 |
ESR peak, mm/h, median (IQR) | 61 (42–79) | 54 (39–68.5) | 68 (59–94) | 0.003 |
Admitted to ICU, (%) | 3 (4) | 0 (0) | 3 (9.7) | 0.067 |
≥2 surgeries, n (%) | 16 (21.3) | 7 (15.9) | 9 (29) | 0.172 |
Days of IV antibiotic, median (IQR) | 10 (5–15) | 6 (4–10) | 16(13–27) | <0.001 |
Days of total antibiotic, median (IQR) | 25 (21–32.5) | 21 (21–26) | 32 (26–44) | <0.001 |
LOS, days, median (IQR) | 10 (5–16) | 6 (4–11) | 16 (11–23) | <0.001 |
Complications, n (%) | 15 (20) | 5 (11.4) | 10 (32.3) | 0.026 |
Sequelae at 6 months, n (%) | 3/73(4.1) | 0/43 | 3/30 (10) | 0.065 |
Predicted K. kingae | ||||
---|---|---|---|---|
Observed | No | yes | % Correct | |
K. kingae | No | 26 | 5 | 83.9 |
Yes | 5 | 38 | 88.4 | |
86.5 |
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Gouveia, C.; Subtil, A.; Norte, S.; Arcangelo, J.; Santos, M.A.; Corte-Real, R.; Simões, M.J.; Canhão, H.; Tavares, D. Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children. Microorganisms 2022, 10, 1233. https://doi.org/10.3390/microorganisms10061233
Gouveia C, Subtil A, Norte S, Arcangelo J, Santos MA, Corte-Real R, Simões MJ, Canhão H, Tavares D. Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children. Microorganisms. 2022; 10(6):1233. https://doi.org/10.3390/microorganisms10061233
Chicago/Turabian StyleGouveia, Catarina, Ana Subtil, Susana Norte, Joana Arcangelo, Madalena Almeida Santos, Rita Corte-Real, Maria João Simões, Helena Canhão, and Delfin Tavares. 2022. "Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children" Microorganisms 10, no. 6: 1233. https://doi.org/10.3390/microorganisms10061233
APA StyleGouveia, C., Subtil, A., Norte, S., Arcangelo, J., Santos, M. A., Corte-Real, R., Simões, M. J., Canhão, H., & Tavares, D. (2022). Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children. Microorganisms, 10(6), 1233. https://doi.org/10.3390/microorganisms10061233