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Review

Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury

1
Neuroscience Department, Medical Toxicology Division, U.S. Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Rd., Aberdeen Proving Ground, MD 21010, USA
2
Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA
3
Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA
4
Biotechnology, Protein Bioinformatics, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Advanced Academic Programs, 9601 Medical Center Drive, Rockville, MD 20850, USA
5
Department of Military and Emergency Medicine, Uniformed Services University of Health Sciences, 3154 Jones Bridge Rd., Bethesda, MD 20814, USA
6
Department of Neurosurgery, Clinical Neurosciences, University of Utah, 175 N Medical Drive East, Salt Lake City, UT 84132, USA
*
Author to whom correspondence should be addressed.
Academic Editor: M. Javad Aman
Microorganisms 2022, 10(5), 886; https://doi.org/10.3390/microorganisms10050886
Received: 23 December 2021 / Revised: 29 March 2022 / Accepted: 17 April 2022 / Published: 24 April 2022
(This article belongs to the Special Issue Gram Positive Toxins Producing Organisms)
Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a number of factors including the mechanism and severity of the trauma, the distance from injury to the reinnervation target, connective tissue sheath integrity, and delay between injury and treatment. Even though modern surgical procedures have greatly improved the success rate, many peripheral nerve injuries still culminate in persistent neuropathic pain and incomplete functional recovery. Recent studies in animals suggest that botulinum neurotoxin A (BoNT/A) can accelerate nerve regeneration and improve functional recovery after injury to peripheral nerves. Possible mechanisms of BoNT/A action include activation or proliferation of support cells (Schwann cells, mast cells, and macrophages), increased angiogenesis, and improvement of blood flow to regenerating nerves. View Full-Text
Keywords: botulinum neurotoxin A; BoNT/A; conditioning lesion; chronic constriction injury; crush injury; peripheral nerve injury; PNI; nerve regeneration; reinnervation; Schwann cells; angiogenesis botulinum neurotoxin A; BoNT/A; conditioning lesion; chronic constriction injury; crush injury; peripheral nerve injury; PNI; nerve regeneration; reinnervation; Schwann cells; angiogenesis
MDPI and ACS Style

Adler, M.; Pellett, S.; Sharma, S.K.; Lebeda, F.J.; Dembek, Z.F.; Mahan, M.A. Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury. Microorganisms 2022, 10, 886. https://doi.org/10.3390/microorganisms10050886

AMA Style

Adler M, Pellett S, Sharma SK, Lebeda FJ, Dembek ZF, Mahan MA. Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury. Microorganisms. 2022; 10(5):886. https://doi.org/10.3390/microorganisms10050886

Chicago/Turabian Style

Adler, Michael, Sabine Pellett, Shashi K. Sharma, Frank J. Lebeda, Zygmunt F. Dembek, and Mark A. Mahan. 2022. "Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury" Microorganisms 10, no. 5: 886. https://doi.org/10.3390/microorganisms10050886

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