Next Article in Journal
Tripartite Interactions among Ixodiphagus hookeri, Ixodes ricinus and Deer: Differential Interference with Transmission Cycles of Tick-Borne Pathogens
Previous Article in Journal
Vaccine-Mediated Mechanisms Controlling Francisella tularensis SCHU S4 Growth in a Rat Co-Culture System
Previous Article in Special Issue
The Role of the Maridi Dam in Causing an Onchocerciasis-Associated Epilepsy Epidemic in Maridi, South Sudan: An Epidemiological, Sociological, and Entomological Study
Open AccessArticle

Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic

1
Global Health Institute, University of Antwerp, 2610 Antwerp, Belgium
2
INSERM, University of Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, 87000 Limoges, France
3
Faculté des Sciences de la Santé, Université de Bangui, Bangui BP:3183, Central African Republic
4
Onchocerciasis Control Programme, Neglected Disease Control Programme, Bangui P.O. Box 883, Central African Republic
5
HILPharma Organization, Yaoundé P.O. Box 25625, Cameroon
6
Association to Promote Neurosciences (APRONES), Kinshasa XI P.O. Box 127, Democratic Republic of the Congo
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(5), 337; https://doi.org/10.3390/pathogens9050337
Received: 25 March 2020 / Revised: 28 April 2020 / Accepted: 29 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Onchocerciasis and River Epilepsy)
Recently, there were anecdotal reports of a high number of persons with epilepsy, including children with nodding seizures in the Landja Mboko area located about 9 km from the capital city Bangui, Central African Republic. We suspected the area to be endemic for onchocerciasis, and that the alleged increase in the number of epilepsy cases was due to ongoing Onchocerca volvulus transmission. However, ivermectin mass drug distribution (MDA) had never been implemented in the area. Therefore we performed an Ov16 antibody prevalence study among children, aged 6–9 years, using the biplex rapid diagnostic test (SD Bioline Oncho/LF biplex IgG4 RDT). The overall Ov16 seroprevalence was 8.9%, and that of lymphatic filariasis (LF) was 1.9%. Ov16 seropositivity was highest in Kodjo (20.0%), a village close to rapids on the river. Our study shows that there is ongoing O. volvulus transmission in the Landja Mboko area. We recommend that the extent of this onchocerciasis focus should be mapped, and the introduction of ivermectin MDA should be considered in these communities. View Full-Text
Keywords: onchocerciasis; epilepsy; Ov16 seroprevalence; children; Central African Republic onchocerciasis; epilepsy; Ov16 seroprevalence; children; Central African Republic
Show Figures

Figure 1

MDPI and ACS Style

de Smet, E.; Metanmo, S.; Mbelesso, P.; Kemata, B.; Siewe Fodjo, J.N.; Boumédiène, F.; Ekwoge, H.T.; Yangatimbi, E.; Ajzenberg, D.; Badibanga, O.; Preux, P.-M.; Colebunders, R. Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic. Pathogens 2020, 9, 337.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop