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Open AccessReview

Tools for Molecular Epidemiology of Streptococcus suis

1
Department of General Sciences, Faculty of Science and Engineering, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand
2
Public Health Ontario, Toronto Laboratory, Toronto, ON M5G 1M1, Canada
3
Department of Laboratory Medicine and Pathobiology, and Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 1A1, Canada
4
Faculty of Veterinary Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
5
Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(2), 81; https://doi.org/10.3390/pathogens9020081
Received: 28 November 2019 / Revised: 22 January 2020 / Accepted: 23 January 2020 / Published: 27 January 2020
Diseases caused by Streptococcus suis are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between S. suis strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of S. suis populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. Here, we review these and other molecular approaches that can be used for surveillance, outbreak tracking, preventative health management, effective treatment and control, as well as vaccine development, including PCR based-assays that are easy to apply in modest diagnostic settings and which allow for the rapid screening of a large number of isolates at relatively low cost, granting the identification of several major clonal complexes of the S. suis population.
Keywords: Streptococcus suis; clonal complex; multilocus sequence typing (MLST), PCR; minimum core genome sequence typing (MCG), pathotyping Streptococcus suis; clonal complex; multilocus sequence typing (MLST), PCR; minimum core genome sequence typing (MCG), pathotyping
MDPI and ACS Style

Hatrongjit, R.; Fittipaldi, N.; Gottschalk, M.; Kerdsin, A. Tools for Molecular Epidemiology of Streptococcus suis. Pathogens 2020, 9, 81.

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