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Pathogens
Volume 9
Issue 12
10.3390/pathogens9120998
Review Report
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Case Report
Peer-Review Record

More than Garden Variety: Massive Vegetations from Infective Endocarditis

Pathogens 2020, 9(12), 998; https://doi.org/10.3390/pathogens9120998
by Christopher Radcliffe 1,*, Joyce Oen-Hsiao 1,2 and Matthew Grant 1,3
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Pathogens 2020, 9(12), 998; https://doi.org/10.3390/pathogens9120998
Submission received: 8 November 2020 / Revised: 26 November 2020 / Accepted: 27 November 2020 / Published: 29 November 2020

Round 1

Reviewer 1 Report

1.- Degree of interest: HIG

The manuscript is of interest because the authors describe a very interesting case report, accompanied by a  systematic literature review and summarized all case reports involving  >4 cm vegetations and the other dramatic presentations of infective endocarditis.

2.- PRESENTATION

The description of the case report is well expressed in the text, as well as the images of the complications of infective endocarditis .The presentation, language, figure and table  are adequate, clear and educational

3.- DISCUSSION

The authors  make a detailed discussion with an comprehensive summary of the cases reported with vegetations> 4 cm , detailing the year and location of the report,  the age of the patient,  the pathogen, the area of involvement,  the Maximum length of vegetation (cm), the  surgical intervention, the pathogen-specific antimicrobial teraphy, and outcome

4.- BIBLIOGRAPHY

It is adequate, up-to-date

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The manuscript “More than Garden Variety: Massive Vegetations from Infective Endocarditis“ by Radcliffe et al. describes a case report of a 39y old patient, who is an i.v. drug abuser and who presents with a large vegetation of the tricuspid valve, which enlarged during the first 24h within the hospital and which was due to MRSA. The patient had a history of earlier MRSA abscesses, arthritis and pneumonia. She underwent surgery of her valve and after some early complications she was discharged on day 18 with further vancomycin treatment.

Although the vegetation is extremely large, there is nothing special in this case.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

The manuscript "More than Garden Variety: Massive Vegetations from Infective Endocarditis" reports the case of infective endocarditis,presenting  huge vegetation on the tricuspid valve.The case is presented thoroughly,including  bacteriological data,imaging investigations,medications and surgery.The authors also presented a systematic literature review and summarized 23 found case reports involving >4 cm vegetations,describing demographic data,pathogen,area of involvment, length of vegetation,sugery type, antibiotic treatment and outcome. Presented data is interesting and widens the understanding of complicated and uncommon presentation of infective endocarditis.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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