COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome
1
Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
2
Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
3
Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(11), 965; https://doi.org/10.3390/pathogens9110965
Received: 21 September 2020
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Revised: 11 November 2020
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Accepted: 17 November 2020
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Published: 19 November 2020
(This article belongs to the Section Human Pathogens)
Coronavirus 2019 (COVID-19) has been reported to trigger Guillain–Barré syndrome (GBS). While uncommon, recurrent GBS (rGBS) episodes, triggered by antecedent viral infections, have been reported in a small proportion of GBS patients, here we describe a patient with a recurrent case of GBS, occurring secondary to COVID-19 infection. Before this patient’s episode, he had two prior GBS flares, each precipitated by a viral infection followed by complete recovery besides intermittent paresthesias. We also consider the nosology of this illness in the spectrum of rGBS and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), with their differing natural histories, prognosis, and therapeutic approaches. For patients who have a history of inflammatory demyelinating polyradiculopathies who develop COVID-19, we recommend close observation for neurologic symptoms over the next days and weeks.
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Keywords:
SARS-CoV-2 neurological complications; recurrent Guillain–Barré syndrome; para-infectious Guillain–Barré syndrome; Chronic Inflammatory Demyelinating Neuropathy; demyelinating polyradiculopathies
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MDPI and ACS Style
McDonnell, E.P.; Altomare, N.J.; Parekh, Y.H.; Gowda, R.C.; Parikh, P.D.; Lazar, M.H.; Blaser, M.J. COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome. Pathogens 2020, 9, 965. https://doi.org/10.3390/pathogens9110965
AMA Style
McDonnell EP, Altomare NJ, Parekh YH, Gowda RC, Parikh PD, Lazar MH, Blaser MJ. COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome. Pathogens. 2020; 9(11):965. https://doi.org/10.3390/pathogens9110965
Chicago/Turabian StyleMcDonnell, Erin P., Nicole J. Altomare, Yesha H. Parekh, Ram C. Gowda, Payal D. Parikh, Mark H. Lazar, and Martin J. Blaser. 2020. "COVID-19 as a Trigger of Recurrent Guillain–Barré Syndrome" Pathogens 9, no. 11: 965. https://doi.org/10.3390/pathogens9110965
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