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Pathogens 2017, 6(4), 55;

The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids

Department of Microbiology, Instituto Aggeu Magalhães, Fiocruz, Recife 50740-465, PE, Brazil
Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Author to whom correspondence should be addressed.
Received: 20 September 2017 / Revised: 21 October 2017 / Accepted: 22 October 2017 / Published: 27 October 2017
(This article belongs to the Special Issue Trypanosoma brucei)
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Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional control mechanisms, such as control of mRNA turnover and selection of mRNA for translation, that may modulate protein synthesis in response to several environmental conditions found in different hosts. In other eukaryotes, selection of mRNA for translation is mediated by the complex eIF4F, a heterotrimeric protein complex composed by the subunits eIF4E, eIF4G, and eIF4A, where the eIF4E binds to the 5′-cap structure of mature mRNAs. In this review, we present and discuss the characteristics of six trypanosomatid eIF4E homologs and their associated proteins that form multiple eIF4F complexes. The existence of multiple eIF4F complexes in trypanosomatids evokes exquisite mechanisms for differential mRNA recognition for translation. View Full-Text
Keywords: Kinetoplastids; eIF4E; translation initiation Kinetoplastids; eIF4E; translation initiation

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Freire, E.R.; Sturm, N.R.; Campbell, D.A.; de Melo Neto, O.P. The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. Pathogens 2017, 6, 55.

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