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The Host’s Reply to Candida Biofilm

University of Wisconsin-Madison, Departments of Medicine, Medical Microbiology and Immunology, 5203 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA
Academic Editor: Ying-Lien Chen
Pathogens 2016, 5(1), 33;
Received: 15 January 2016 / Revised: 9 March 2016 / Accepted: 10 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Human Fungal Pathogens)
PDF [2628 KB, uploaded 18 March 2016]


Candida spp. are among the most common nosocomial fungal pathogens and are notorious for their propensity toward biofilm formation. When growing on a medical device or mucosal surface, these organisms reside as communities embedded in a protective matrix, resisting host defenses. The host responds to Candida biofilm by depositing a variety of proteins that become incorporated into the biofilm matrix. Compared to free-floating Candida, leukocytes are less effective against Candida within a biofilm. This review highlights recent advances describing the host’s response to Candida biofilms using ex vivo and in vivo models of mucosal and device-associated biofilm infections. View Full-Text
Keywords: Candida; biofilm; host; neutrophil; model; mucosal; defense; matrix; monocyte Candida; biofilm; host; neutrophil; model; mucosal; defense; matrix; monocyte

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nett, J.E. The Host’s Reply to Candida Biofilm. Pathogens 2016, 5, 33.

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