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Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8103, Japan
Author to whom correspondence should be addressed.
Pathogens 2014, 3(2), 377-389;
Received: 6 March 2014 / Revised: 9 April 2014 / Accepted: 11 April 2014 / Published: 23 April 2014
(This article belongs to the Special Issue Animal Model to Study Viral Immunity)
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma. Despite the availability of an HBV vaccine and the development of antiviral therapies, there are still more than 350 million chronically infected people worldwide, approximately 5% of the world population. To understand the virus biology and pathogenesis in HBV-infected patients, several animal models have been developed to mimic hepatic HBV infection and the immune response against HBV, but the narrow host range of HBV infection and lack of a full immune response spectrum in animal models remain significant limitations. Accumulating evidence obtained from studies using a variety of mouse models that recapitulate hepatic HBV infection provides several clues for understanding host-virus immunologic interactions during HBV infection, whereas the determinants of the immune response required for HBV clearance are poorly defined. Therefore, adequate mouse models are urgently needed to elucidate the mechanism of HBV elimination and identify novel targets for antiviral therapies. View Full-Text
Keywords: animal model; transgenic mouse; humanized mouse; immune response animal model; transgenic mouse; humanized mouse; immune response
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Inuzuka, T.; Takahashi, K.; Chiba, T.; Marusawa, H. Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions. Pathogens 2014, 3, 377-389.

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