Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques
Abstract
:1. Introduction
2. Results and Discussion
2.1. Class-C CpG ODNs Treatment Increases Percent Survival in BALB/c Mice
2.2. Class-C CpG ODNs Treatment Reduces Bacterial Load in BALB/c Mice
2.3. Class-C CpG ODNs Treatment Leads to Higher Neutrophil-Specific Fluorescence Signal in BALB/c Mice
2.4. Class-C CpG ODNs Treatment Leads to Increase Levels of Inflammatory Monocytes during Early Infection of BALB/c Mice
2.5. Class-C CpG ODNs Treatment Results in Decreased Tissue Damage in the Lungs
2.6. Discussion of Results
3. Experimental Section
3.1. Bacterial Strain
3.2. Mice
3.3. Ethics Statement
3.4. Survival Studies
3.5. Bacterial Burden
3.6. In vivo Imaging
3.7. Cell Preparation and Flow Cytometry
3.8. Histopathology of the Lungs
4. Conclusions
Acknowledgments
Conflict of Interest
References
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Mott, T.M.; Johnston, R.K.; Vijayakumar, S.; Estes, D.M.; Motamedi, M.; Sbrana, E.; Endsley, J.J.; Torres, A.G. Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques. Pathogens 2013, 2, 383-401. https://doi.org/10.3390/pathogens2020383
Mott TM, Johnston RK, Vijayakumar S, Estes DM, Motamedi M, Sbrana E, Endsley JJ, Torres AG. Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques. Pathogens. 2013; 2(2):383-401. https://doi.org/10.3390/pathogens2020383
Chicago/Turabian StyleMott, Tiffany M., R. Katie Johnston, Sudhamathi Vijayakumar, D. Mark Estes, Massoud Motamedi, Elena Sbrana, Janice J. Endsley, and Alfredo G. Torres. 2013. "Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques" Pathogens 2, no. 2: 383-401. https://doi.org/10.3390/pathogens2020383