Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | n (%) |
---|---|
n = 2509 | |
Age, years | |
0–4 | 551 (22.0) |
5–17 | 354 (14.1) |
18–29 | 453 (18.0) |
30–44 | 658 (26.2) |
45–64 | 428 (17.1) |
≥65 | 31 (1.2) |
Unknown | 34 (1.4) |
Sex | |
Male | 1383 (55.2) |
Female | 1123 (44.8) |
Exposure time | |
≥6 h/day | 1334 (53.2) |
<6 h/day but ≥6 h/week | 443 (17.7) |
<6 h/week | 462 (18.4) |
Sporadic but intense | 172 (6.8) |
Unknown | 98 (3.9) |
Smoker | |
Yes | 393 (15.7) |
No/unknown | 2116 (84.3) |
Place of exposure | |
Home | 1483 (59.1) |
Work | 698 (27.8) |
Recreational area | 94 (3.7) |
School | 194 (7.7) |
Other/unknown | 40 (1.6) |
BCG vaccination | |
Yes | 805 (34.2) |
No/unknown | 1551 (65.8) |
HIV | |
Yes | 12 (0.5) |
No/unknown | 2497 (99.5) |
Diabetes | |
Yes | 42 (1.7) |
No/unknown | 2467 (98.3) |
Cancer | |
Yes | 11 (0.4) |
No/unknown | 2498 (99.6) |
Chronic kidney disease | |
Yes | 7 (0.3) |
No/unknown | 2502 (99.7) |
Index case: positive sputum smear | |
Yes | 1350 (53.8) |
No | 1159 (46.2) |
Index case: X-ray cavitary lesions | |
Yes | 1010 (40.3) |
No | 1499 (59.7) |
Variable | LTBI Yes | LTBI No | |||
---|---|---|---|---|---|
n (%) | n (%) | OR | 95% CI | p * | |
Age, years | |||||
0–4 | 67 (12.2) | 484 (87.8) | 1.0 | Reference | |
5–17 | 132 (37.3) | 222 (62.7) | 4.3 | 3.1–6.0 | <0.001 |
18–29 | 184 (40.6) | 269 (59.4) | 4.9 | 3.6–6.8 | <0.001 |
30–44 | 279 (42.4) | 379 (57.6) | 5.3 | 3.9–7.2 | <0.001 |
45–64 | 247 (57.7) | 181 (42.3) | 9.8 | 7.2–13.6 | <0.001 |
>64 | 21 (67.7) | 10 (32.3) | 15.0 | 6.9–34.7 | <0.001 |
Sex | <0.001 | ||||
Male | 562 (40.6) | 821 (59.4) | 1.4 | 1.2–1.6 | |
Female | 376 (33.5) | 747 (66.5) | 1.0 | Reference | |
Exposure time | |||||
≥6 h/day | 590 (44.2) | 744 (55.8) | 2.5 | 1.9–3.1 | <0.001 |
<6 h/day but ≥6 h/week | 146 (33.0) | 297 (67.0) | 1.5 | 1.1–2.1 | 0.004 |
<6 h/week | 112 (24.2) | 350 (75.8) | 1.0 | Reference | |
Sporadic but intense | 63 (36.6) | 109 (63.4) | 1.8 | 1.2–2.6 | 0.002 |
Smoker | <0.001 | ||||
Yes | 281 (71.5) | 112 (28.5) | 5.6 | 4.4–7.1 | |
No/unknown | 658 (31.1) | 1458 (68.9) | 1.0 | Reference | |
Place of exposure | |||||
Home | 627 (42.3) | 856 (57.7) | 2.4 | 1.7–3.4 | <0.001 |
Work | 226 (32.4) | 472 (67.6) | 1.6 | 1.1–2.3 | 0.017 |
Recreational area | 35 (37.2) | 59 (62.8) | 2.0 | 1.1–3.3 | <0.012 |
School | 45 (23.2) | 149 (76.8) | 1.0 | Reference | <0.001 |
BCG vaccination | <0.001 | ||||
Yes | 346 (43.0) | 459 (57.0) | 1.4 | 1.2–1.7 | |
No/unknown | 541 (34.9) | 1010 (65.1) | 1.0 | Reference | |
HIV | 0.760 | ||||
Yes | 5 (41.7) | 7 (58.3) | 1.2 | 0.4–3.8 | |
No/unknown | 934 (37.4) | 1563 (62.6) | 1.0 | Reference | |
Diabetes | <0.001 | ||||
Yes | 28 (66.7) | 14 (33.3) | 3.4 | 1.8–6.5 | |
No/unknown | 911 (36.9) | 1556 (63.1) | 1.0 | Reference | |
Cancer | 0.015 | ||||
Yes | 8 (72.7) | 3 (27.3) | 4.9 | 1.2–17.0 | |
No/unknown | 541 (34.9) | 1010 (65.1) | 1.0 | Reference | |
Chronic kidney disease | 0.062 | ||||
Yes | 5 (71.4) | 2 (28.6) | 4.2 | 0.8–21.7 | |
No/unknown | 934 (37.3) | 1568 (62.7) | 1.0 | Reference | |
Index case: positive sputum smear | <0.001 | ||||
Yes | 581 (43.0) | 769 (57.0) | 1.7 | 1.4–2.0 | |
No | 358 (30.9) | 801 (69.1) | 1.0 | Reference | |
Index case: X-ray cavitary lesions | <0.001 | ||||
Yes | 448 (44.4) | 562 (55.6) | 1.6 | 1.4–1.9 | |
No | 491 (32.8) | 1008 (67.2) | 1.0 | Reference |
Variable | aOR | 95% CI | p-Value | |
---|---|---|---|---|
Age, years | ||||
0–4 | 1.00 | Reference | ||
5–17 | 6.43 | 4.33 | 9.55 | <0.001 |
18–29 | 4.92 | 3.42 | 7.09 | <0.001 |
30–44 | 5.85 | 4.16 | 8.23 | <0.001 |
45–64 | 11.06 | 7.60 | 16.10 | <0.001 |
>64 | 9.57 | 4.05 | 22.59 | <0.001 |
Sex | ||||
Male | 1.32 | 1.08 | 1.61 | 0.006 |
Female | 1.00 | Reference | ||
Exposure time | ||||
≥6 h/day | 2.03 | 1.50 | 2.73 | <0.001 |
<6 h/day but ≥6 h/week | 1.65 | 1.18 | 2.31 | 0.004 |
<6 h/week | 1.00 | Reference | ||
Sporadic but intense | 1.80 | 1.16 | 2.80 | 0.008 |
Smoker | ||||
Yes | 3.42 | 2.60 | 4.50 | <0.001 |
No | 1.00 | Reference | ||
Place of exposure | ||||
Home | 2.96 | 1.78 | 4.91 | <0.001 |
Work | 1.36 | 0.82 | 2.27 | 0.232 |
Recreational area | 4.31 | 2.08 | 8.95 | <0.001 |
School | 1.00 | - | - | - |
BCG vaccination | ||||
Yes | 1.13 | 0.91 | 1.38 | 0.248 |
No/unknown | 1.00 | Reference | ||
HIV | ||||
Yes | 0.25 | 0.06 | 0.92 | 0.038 |
No/unknown | 1.00 | Reference | ||
Diabetes | ||||
Yes | 1.16 | 0.55 | 2.43 | 0.702 |
No/unknown | 1.00 | Reference | ||
Chronic kidney disease | ||||
Yes | 2.58 | 0.37 | 18.08 | 0.339 |
No/unknown | 1.00 | Reference | ||
Index case: positive sputum smear | ||||
Yes | 1.56 | 1.26 | 1.94 | <0.001 |
No | 1.00 | Reference | ||
Index case: X-ray cavitary lesions | ||||
Yes | 1.40 | 1.13 | 1.74 | 0.002 |
No | 1.00 | Reference |
Variable | Total | IGRA Positive | |||
---|---|---|---|---|---|
n (%) | aOR | 95% CI | p-Value | ||
Age, years | |||||
0–17 | 161 | 10 (6.2) | 1.00 | Reference | |
18–29 | 43 | 8 (18.6) | 6.79 | 1.72–26.78 | 0.006 |
30–44 | 56 | 13 (23.2) | 10.57 | 3.07–36.35 | <0.001 |
45–64 | 37 | 14 (37.8) | 23.51 | 6.37–82.08 | <0.001 |
Sex | 0.960 | ||||
Male | 156 | 26 (16.7) | 0.98 | 0.44–2.20 | |
Female | 141 | 19 (13.5) | 1.00 | Reference | |
Exposure time | |||||
≥6 h/day | 184 | 24 (13.0) | 6.79 | 1.49–30.90 | 0.013 |
<6 h/day but ≥6 h/week | 65 | 14 (21.5) | 10.61 | 2.25–49.94 | 0.003 |
<6 h/week | 32 | 4 (12.5) | 1.00 | Reference | - |
Sporadic but intense | 16 | 3 (18.7) | 3.30 | 0.45–24.11 | 0.239 |
Smoker | 0.133 | ||||
Yes | 31 | 14 (45.2) | 2.36 | 0.77–7.25 | |
No/unknown | 266 | 31 (11.6) | 1.00 | Reference | |
BCG vaccination | 0.004 | ||||
Yes | 172 | 22 (12.8) | 0.26 | 0.10–0.66 | |
No/unknown | 113 | 20 (17.7) | 1.00 | Reference | |
Index case: positive sputum smear | 0.203 | ||||
Yes | 146 | 28 (19.2) | 1.87 | 0.73–7.86 | |
No | 151 | 17 (11.3) | 1.00 | Reference | |
Index case: X-ray cavitary lesions | 0.002 | ||||
Yes | 94 | 28 (29.8) | 3.99 | 1.64–9.66 | |
No | 203 | 17 (8.4) | 1.00 | Reference |
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Godoy, S.; Alsedà, M.; Parrón, I.; Millet, J.-P.; Caylà, J.A.; Follia, N.; Carol, M.; Orcau, A.; Toledo, D.; Ferrús, G.; et al. Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations. Pathogens 2025, 14, 175. https://doi.org/10.3390/pathogens14020175
Godoy S, Alsedà M, Parrón I, Millet J-P, Caylà JA, Follia N, Carol M, Orcau A, Toledo D, Ferrús G, et al. Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations. Pathogens. 2025; 14(2):175. https://doi.org/10.3390/pathogens14020175
Chicago/Turabian StyleGodoy, Sofia, Miquel Alsedà, Ignasi Parrón, Joan-Pau Millet, Joan A. Caylà, Núria Follia, Monica Carol, Angels Orcau, Diana Toledo, Gloria Ferrús, and et al. 2025. "Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations" Pathogens 14, no. 2: 175. https://doi.org/10.3390/pathogens14020175
APA StyleGodoy, S., Alsedà, M., Parrón, I., Millet, J.-P., Caylà, J. A., Follia, N., Carol, M., Orcau, A., Toledo, D., Ferrús, G., Plans, P., Barrabeig, I., Clotet, L., Domínguez, A., March-Llanes, J., Godoy, P., & on behalf of the Transmission of Tuberculosis in Catalonia (Spain) Working Group. (2025). Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations. Pathogens, 14(2), 175. https://doi.org/10.3390/pathogens14020175