Next Article in Journal
Lyme Carditis: From Pathophysiology to Clinical Management
Previous Article in Journal
Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
Previous Article in Special Issue
Identification of Salicylic Acid Mechanism against Leaf Blight Disease in Oryza sativa by SR-FTIR Microspectroscopic and Docking Studies
 
 
Article

Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions

Department of Biological Sciences, Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Shishir K. Gupta, Mugdha Srivastava and Thomas Dandekar
Pathogens 2022, 11(5), 583; https://doi.org/10.3390/pathogens11050583
Received: 18 March 2022 / Revised: 6 May 2022 / Accepted: 11 May 2022 / Published: 15 May 2022
(This article belongs to the Special Issue Computational Biology Applied to Host-Pathogen Interactions)
Protein-protein interactions drive functions in eukaryotes that can be described by short linear motifs (SLiMs). Conservation of SLiMs help illuminate functional SLiMs in eukaryotic protein families. However, the simplicity of eukaryotic SLiMs makes them appear by chance due to mutational processes not only in eukaryotes but also in pathogenic bacteria and viruses. Further, functional eukaryotic SLiMs are often found in disordered regions. Although proteomes from pathogenic bacteria and viruses have less disorder than eukaryotic proteomes, their proteins can successfully mimic eukaryotic SLiMs and disrupt host cellular function. Identifying important SLiMs in pathogens is difficult but essential for understanding potential host-pathogen interactions. We performed a comparative analysis of structural features for experimentally verified SLiMs from the Eukaryotic Linear Motif (ELM) database across viruses, bacteria, and eukaryotes. Our results revealed that many viral SLiMs and specific motifs found across viruses and eukaryotes, such as some glycosylation motifs, have less disorder. Analyzing the disorder and coil properties of equivalent SLiMs from pathogens and eukaryotes revealed that some motifs are more structured in pathogens than their eukaryotic counterparts and vice versa. These results support a varying mechanism of interaction between pathogens and their eukaryotic hosts for some of the same motifs. View Full-Text
Keywords: short linear motifs; SLiMs; ELM database; intrinsic disordered protein regions; molecular mimicry; protein flexibility short linear motifs; SLiMs; ELM database; intrinsic disordered protein regions; molecular mimicry; protein flexibility
Show Figures

Figure 1

MDPI and ACS Style

Elkhaligy, H.; Balbin, C.A.; Siltberg-Liberles, J. Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions. Pathogens 2022, 11, 583. https://doi.org/10.3390/pathogens11050583

AMA Style

Elkhaligy H, Balbin CA, Siltberg-Liberles J. Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions. Pathogens. 2022; 11(5):583. https://doi.org/10.3390/pathogens11050583

Chicago/Turabian Style

Elkhaligy, Heidy, Christian A. Balbin, and Jessica Siltberg-Liberles. 2022. "Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions" Pathogens 11, no. 5: 583. https://doi.org/10.3390/pathogens11050583

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop