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Pathogens
Volume 11
Issue 2
10.3390/pathogens11020132
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Review

Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives

by
Julio C. Osorio
1,
Rancés Blanco
2,
Alejandro H. Corvalán
3,
Juan P. Muñoz
4,
Gloria M. Calaf
4,5 and
Francisco Aguayo
6,*
1
Population Registry of Cali, Department of Pathology, Universidad del Valle, Cali 760042, Colombia
2
Laboratorio de Oncovirología, Programa de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile
3
Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
4
Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile
5
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
6
Universidad de Tarapacá, Arica 1000000, Chile
*
Author to whom correspondence should be addressed.
Pathogens 2022, 11(2), 132; https://doi.org/10.3390/pathogens11020132
Submission received: 15 December 2021 / Revised: 17 January 2022 / Accepted: 17 January 2022 / Published: 21 January 2022
(This article belongs to the Collection Feature Papers in Viral Pathogens)
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Abstract

Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein–Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.
Keywords: Epstein–Barr virus; cancer; lung Epstein–Barr virus; cancer; lung

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MDPI and ACS Style

Osorio, J.C.; Blanco, R.; Corvalán, A.H.; Muñoz, J.P.; Calaf, G.M.; Aguayo, F. Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives. Pathogens 2022, 11, 132. https://doi.org/10.3390/pathogens11020132

AMA Style

Osorio JC, Blanco R, Corvalán AH, Muñoz JP, Calaf GM, Aguayo F. Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives. Pathogens. 2022; 11(2):132. https://doi.org/10.3390/pathogens11020132

Chicago/Turabian Style

Osorio, Julio C., Rancés Blanco, Alejandro H. Corvalán, Juan P. Muñoz, Gloria M. Calaf, and Francisco Aguayo. 2022. "Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives" Pathogens 11, no. 2: 132. https://doi.org/10.3390/pathogens11020132

APA Style

Osorio, J. C., Blanco, R., Corvalán, A. H., Muñoz, J. P., Calaf, G. M., & Aguayo, F. (2022). Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives. Pathogens, 11(2), 132. https://doi.org/10.3390/pathogens11020132

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