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Article

Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats

by 1,*,†, 1,†, 1,†, 2,* and 3,*
1
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
2
Agricultural College, Jinhua Polytechnic, Jinhua 321007, China
3
School of STEM, Kentucky State University, Frankfort, KY 40601, USA
*
Authors to whom correspondence should be addressed.
These authors are contributed equally to this work.
Academic Editor: George Valiakos
Pathogens 2021, 10(10), 1320; https://doi.org/10.3390/pathogens10101320
Received: 25 August 2021 / Revised: 23 September 2021 / Accepted: 1 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Epidemiological Study of Infectious Diseases of Animals)
Cats are susceptible to a wide range of influenza A viruses (IAV). Furthermore, cats can serve as an intermediate host, and transfer avian influenza virus (AIV) H7N2 to a veterinarian. In this report, a novel reassortant influenza virus, designated A/feline/Jiangsu/HWT/2017 (H3N2), and abbreviated as FIV-HWT-2017, was isolated from nasal swab of a symptomatic cat in Jiangsu province, China. Sequence analysis indicated that, whilst the other seven genes were most similar to the avian-origin canine influenza viruses (CIV H3N2) isolated in China, the NS gene was more closely related to the circulating human influenza virus (H3N2) in the region. Therefore, FIV-HWT-2017 is a reassortant virus. In addition, some mutations were identified, and they were similar to a distinctive CIV H3N2 clade. Whether these cats were infected with the reassortant virus was unknown, however, this random isolation of a reassortant virus indicated that domestic or stray cats were “mixing vessel” for IAV cannot be ruled out. An enhanced surveillance for novel influenza virus should include pet and stray cats. View Full-Text
Keywords: novel influenza virus; cats; reassortant novel influenza virus; cats; reassortant
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MDPI and ACS Style

Zhao, J.; He, W.; Lu, M.; He, H.; Lai, A. Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats. Pathogens 2021, 10, 1320. https://doi.org/10.3390/pathogens10101320

AMA Style

Zhao J, He W, Lu M, He H, Lai A. Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats. Pathogens. 2021; 10(10):1320. https://doi.org/10.3390/pathogens10101320

Chicago/Turabian Style

Zhao, Jin, Wanting He, Meng Lu, Haijian He, and Alexander Lai. 2021. "Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats" Pathogens 10, no. 10: 1320. https://doi.org/10.3390/pathogens10101320

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