Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats
Abstract
:1. Introduction
2. Material and Method
2.1. Virus Isolation
2.2. RT-PCR, Sequencing and Analysis of Sequences
3. Results
3.1. Virus Isolation
3.2. Nucleotide Sequencing and Phylogenetic Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene | Nucleotide Sequence Compared | Identity (%) | Virus Designation | GenBank Accession Number |
---|---|---|---|---|
PB2 | 2280 | 98.6 | A/canine/Guangdong/12/2012 (H3N2) | KF826944 |
PB1 | 2274 | 98.1 | A/canine/Guangdong/12/2012 (H3N2) | KF826945 |
PA | 2151 | 98.7 | A/canine/Guangdong/12/2012 (H3N2) A/canine/Heilongjiang/L1/2013(H3N2) | KF826946 KF042275 |
HA | 1701 | 98.2 | A/canine/Nanjing/11/2012 (H3N2) | KF322105 |
NP | 1497 | 99.8 | A/canine/Guangdong/05/2011 (H3N2) | JX414247 |
NA | 1417 | 98.7 | A/canine/Nanjing/11/2012(H3N2) | KF322106 |
M | 982 | 99.0 | A/canine/Guangdong/12/2012(H3N2) | KF826950 |
NS | 838 | 99.42 | A/Victoria/55/2015(H3N2) | CY253950 |
HA | NA | M2 | PB2 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Strains | Cleavage Site | Receptor Binding Sites | Insertion | Oseltamivir-Resistant Amino Acids | Amantadine Resistant Amino Acids | Virulence Determinant | |||||||
324–332 | 226 | 228 | 75–77 | 119 | 222 | 274 | 292 | 26 | 27 | 30 | 31 | 627 | |
F-JS-17 | PERQTRGLL | Q | G | KEI | E | I | H | R | L | V | A | S | E |
F-Kor-10 | PERQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
F-Kor-FY-10 | PERQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
F-HLJ-14 | PERQTRGLF | Q | G | KEI | E | I | H | R | L | V | A | S | E |
F-GD-11 | PEKQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
F-GD-12 | PEKQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | N | E |
C-GX-12 | PEKQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
D-JS-04 | PEKQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
Can-NJ-12 | PERQTRGLF | Q | G | KEI | E | I | H | R | no | no | no | no | no |
Can-GD-12 | PERQTRGLF | Q | G | - - - | E | I | H | R | L | V | A | S | E |
Can-HLJ-13 | PERQTRGLF | Q | G | KEI | E | I | H | R | L | V | A | S | E |
Can-Kor-15 | PERQTRGLF | Q | G | - - - | E | I | H | R | L | I | A | S | E |
Can-USA-16 | PERQTRGLF | Q | G | - - - | E | I | H | R | L | I | A | S | E |
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Zhao, J.; He, W.; Lu, M.; He, H.; Lai, A. Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats. Pathogens 2021, 10, 1320. https://doi.org/10.3390/pathogens10101320
Zhao J, He W, Lu M, He H, Lai A. Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats. Pathogens. 2021; 10(10):1320. https://doi.org/10.3390/pathogens10101320
Chicago/Turabian StyleZhao, Jin, Wanting He, Meng Lu, Haijian He, and Alexander Lai. 2021. "Emergence and Characterization of a Novel Reassortant Canine Influenza Virus Isolated from Cats" Pathogens 10, no. 10: 1320. https://doi.org/10.3390/pathogens10101320