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Open AccessFeature PaperArticle

Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants

1
National Institute for Lasers, Plasma and Radiation Physics, RO-077125 Magurele-Ilfov, Romania
2
Department of Physics, Faculty of Applied Sciences, University Politehnica of Bucharest, RO-060042 Bucharest, Romania
3
National Institute for Mechatronics & Measurement Technique, RO-021631 Bucharest, Romania
4
Department of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, RO-060031 Bucharest, Romania
5
National Institute for Materials Physics, RO-077125 Magurele-Ilfov, Romania
6
Army Centre for Medical Research, RO-010195 Bucharest, Romania
7
Center for Nanotechnology & Biomaterials Research, University of Marmara, Goztepe Campus, 34722 Istanbul, Turkey
8
Department of Bioengineering, Faculty of Engineering, University of Marmara, Goztepe Campus, 34722 Istanbul, Turkey
*
Authors to whom correspondence should be addressed.
Metals 2019, 9(12), 1332; https://doi.org/10.3390/met9121332
Received: 18 November 2019 / Revised: 6 December 2019 / Accepted: 9 December 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Metal Additive Manufacturing – State of the Art 2020)
Ti6Al4V cranial prostheses in the form of patterned meshes were 3D printed by selective laser melting in an argon environment; using a CO2 laser source and micron-sized Ti6Al4V powder as the starting material. The size and shape of prostheses were chosen based on actual computer tomography images of patient skull fractures supplied in the framework of a collaboration with a neurosurgery clinic. After optimizations of scanning speed and laser parameters, the printed material was defect-free (as shown by metallographic analyses) and chemically homogeneous, without elemental segregation or depletion. The prostheses were coated by radio-frequency magnetron sputtering (RF-MS) with a bioactive thin layer of hydroxyapatite using a bioceramic powder derived from biogenic resources (Bio-HA). Initially amorphous, the films were converted to fully-crystalline form by applying a post-deposition thermal-treatment at 500 °C/1 h in air. The X-ray diffraction structural investigations indicated the phase purity of the deposited films composed solely of a hexagonal hydroxyapatite-like compound. On the other hand, the Fourier transform infrared spectroscopic investigations revealed that the biological carbonatation of the bone mineral phase was well-replicated in the case of crystallized Bio-HA RF-MS implant coatings. The in vitro acellular assays, performed in both the fully inorganic Kokubo’s simulated body fluid and the biomimetic organic–inorganic McCoy’s 5A cell culture medium up to 21 days, emphasized both the good resistance to degradation and the biomineralization capacity of the films. Further in vitro tests conducted in SaOs-2 osteoblast-like cells showed a positive proliferation rate on the Bio-HA RF-MS coating along with a good adhesion developed on the biomaterial surface by elongated membrane protrusions. View Full-Text
Keywords: biological origin hydroxyapatite; bioactive layers; cranial mesh implants; selective laser melting; 3D printing; radio-frequency magnetron sputtering biological origin hydroxyapatite; bioactive layers; cranial mesh implants; selective laser melting; 3D printing; radio-frequency magnetron sputtering
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MDPI and ACS Style

Chioibasu, D.; Duta, L.; Popescu-Pelin, G.; Popa, N.; Milodin, N.; Iosub, S.; Balescu, L.M.; Catalin Galca, A.; Claudiu Popa, A.; Oktar, F.N.; Stan, G.E.; Popescu, A.C. Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants. Metals 2019, 9, 1332. https://doi.org/10.3390/met9121332

AMA Style

Chioibasu D, Duta L, Popescu-Pelin G, Popa N, Milodin N, Iosub S, Balescu LM, Catalin Galca A, Claudiu Popa A, Oktar FN, Stan GE, Popescu AC. Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants. Metals. 2019; 9(12):1332. https://doi.org/10.3390/met9121332

Chicago/Turabian Style

Chioibasu, Diana; Duta, Liviu; Popescu-Pelin, Gianina; Popa, Nicoleta; Milodin, Nichita; Iosub, Stefana; Balescu, Liliana M.; Catalin Galca, Aurelian; Claudiu Popa, Adrian; Oktar, Faik N.; Stan, George E.; Popescu, Andrei C. 2019. "Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants" Metals 9, no. 12: 1332. https://doi.org/10.3390/met9121332

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