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Collagen-Nanoparticles Composites for Wound Healing and Infection Control

Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 313 Independenţei Avenue, Sector 6, 060042 Bucharest, Romania
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Gheorghe Polizu Street, Sector 1, 011061 Bucharest, Romania
Academy of Romanian Scientists (AOSR), 54 Independenţei Avenue, Sector 5, 050085 Bucharest, Romania
Division of Earth, Environmental and Life Sciences, Faculty of Biology, Research Institute of the University of Bucharest (ICUB), 1–3 Portocalelor Lane, Sector 6, 060101 Bucharest, Romania
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania
Author to whom correspondence should be addressed.
Metals 2017, 7(12), 516;
Received: 7 October 2017 / Revised: 9 November 2017 / Accepted: 15 November 2017 / Published: 23 November 2017
(This article belongs to the Special Issue Metallic and Metal Oxide Nanoparticles: Novel Approaches)
Nowadays, the world is facing a serious crisis represented by the rapid emergence of resistant bacteria, which jeopardizes the efficacy of antibiotics. This crisis has been attributed to the overuse and misuse of antibiotics, as well as the cessation of new drug production by the pharmaceutical industry. Therefore, bacterial strains with resistance to multiple antibiotic classes have appeared, such as Staphylococcus aureus, Acinetobacter spp. and Pseudomonas aeruginosa. This review aims to provide an updated summary of the current approach to the treatment of infections due to resistant microorganisms, with a focus on the application of the antimicrobial effects of inorganic nanoparticles in combination with collagen to promote wound healing. In addition, the paper describes the current approaches in the field of functionalized collagen hydrogels capable of wound healing and inhibiting microbial biofilm production. View Full-Text
Keywords: collagen; hydrogels; nanoparticles; wound healing; antimicrobial therapy collagen; hydrogels; nanoparticles; wound healing; antimicrobial therapy
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Grigore, M.E.; Grumezescu, A.M.; Holban, A.M.; Mogoşanu, G.D.; Andronescu, E. Collagen-Nanoparticles Composites for Wound Healing and Infection Control. Metals 2017, 7, 516.

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