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Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise

1
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
2
Department of Vascular Surgery, Oslo University Hospital, 0424 Oslo, Norway
3
Department of Prehospital Care, Vestfold Hospital Trust, 3103 Toensberg, Norway
4
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, 0424 Oslo, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony Leicht
Sports 2021, 9(6), 86; https://doi.org/10.3390/sports9060086
Received: 30 April 2021 / Revised: 14 June 2021 / Accepted: 16 June 2021 / Published: 17 June 2021
We assessed endothelial function by flow-mediated dilatation (FMD), levels of the NO-precursor L-arginine, and markers of endothelial inflammation before, at the finish line, and one week after the Norseman Xtreme triathlon. The race is an Ironman distance triathlon with a total elevation of 5200 m. Nine male participants were included. They completed the race in 14.5 (13.4–15.3) h. FMD was significantly reduced to 3.1 (2.1–5.0)% dilatation compared to 8.7 (8.2–9.3)% dilatation before the race (p < 0.05) and was normalized one week after the race. L-arginine showed significantly reduced levels at the finish line (p < 0.05) but was normalized one week after the race. Markers of endothelial inflammation E-Selectin, VCAM-1, and ICAM-1 all showed a pattern with increased values at the finish line compared to before the race (all p < 0.05), with normalization one week after the race. In conclusion, we found acutely reduced FMD with reduced L-arginine levels and increased E-Selectin, VCAM-1, and ICAM-1 immediately after the Norseman Xtreme triathlon. Our findings indicate a transient reduced endothelial function, measured by the FMD-response, after prolonged strenuous exercise that could be explained by reduced NO-precursor L-arginine levels and increased endothelial inflammation. View Full-Text
Keywords: FMD; endothelium; NO; inflammation; ironman; triathlon; E-selectin; VCAM-1; ICAM-1; L-arginine FMD; endothelium; NO; inflammation; ironman; triathlon; E-selectin; VCAM-1; ICAM-1; L-arginine
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MDPI and ACS Style

Nyborg, C.; Melsom, H.S.; Bonnevie-Svendsen, M.; Melau, J.; Seljeflot, I.; Hisdal, J. Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise. Sports 2021, 9, 86. https://doi.org/10.3390/sports9060086

AMA Style

Nyborg C, Melsom HS, Bonnevie-Svendsen M, Melau J, Seljeflot I, Hisdal J. Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise. Sports. 2021; 9(6):86. https://doi.org/10.3390/sports9060086

Chicago/Turabian Style

Nyborg, Christoffer, Helene S. Melsom, Martin Bonnevie-Svendsen, Jørgen Melau, Ingebjørg Seljeflot, and Jonny Hisdal. 2021. "Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise" Sports 9, no. 6: 86. https://doi.org/10.3390/sports9060086

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