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Article

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study

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School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia
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Institute for Health Research, University of Notre Dame Australia, Perth 6160, Australia
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School of Health Science, University of Notre Dame Australia, Perth 6160, Australia
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Perron Institute for Neurological and Translational Science, Perth 6009, Australia
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Centre for Exercise and Sport Science Research, Edith Cowan University, Perth 6027, Australia
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West Coast Eagles Football Club, Perth 6100, Australia
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Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia
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Faculty of Health Sciences, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth 6102, Australia
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Exercise Medicine Research Institute, Edith Cowan University, Perth 6027, Australia
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Faculty of Health, Queensland University of Technology, Brisbane 4059, Australia
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Authors to whom correspondence should be addressed.
Sports 2021, 9(2), 22; https://doi.org/10.3390/sports9020022
Received: 6 September 2020 / Revised: 21 January 2021 / Accepted: 26 January 2021 / Published: 29 January 2021
Genetic variants in the angiotensin-converting enzyme (ACE) (rs4343), alpha-actinin-3 (ACTN3) (rs1815739), adrenoceptor-beta-1 (ADRB1) (rs1801253), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) (rs8192678) genes have previously been associated with elite athletic performance. This study assessed the influence of polymorphisms in these candidate genes towards endurance test performance in 46 players from a single Australian Football League (AFL) team. Each player provided saliva buccal swab samples for DNA analysis and genotyping and were required to perform two independent two-kilometre running time-trials, six weeks apart. Linear mixed models were created to account for repeated measures over time and to determine whether player genotypes are associated with overall performance in the two-kilometre time-trial. The results showed that the ADRB1 Arg389Gly CC (p = 0.034) and PPARGC1A Gly482Ser GG (p = 0.031) genotypes were significantly associated with a faster two-kilometre time-trial. This is the first study to link genetic polymorphism to an assessment of endurance performance in Australian Football and provides justification for further exploratory or confirmatory studies. View Full-Text
Keywords: ADRB1; PPARGC1a; genes; sport; performance; Australian Football; endurance ADRB1; PPARGC1a; genes; sport; performance; Australian Football; endurance
MDPI and ACS Style

Jacob, Y.; Anderton, R.S.; Cochrane Wilkie, J.L.; Rogalski, B.; Laws, S.M.; Jones, A.; Spiteri, T.; Hart, N.H. Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study. Sports 2021, 9, 22. https://doi.org/10.3390/sports9020022

AMA Style

Jacob Y, Anderton RS, Cochrane Wilkie JL, Rogalski B, Laws SM, Jones A, Spiteri T, Hart NH. Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study. Sports. 2021; 9(2):22. https://doi.org/10.3390/sports9020022

Chicago/Turabian Style

Jacob, Ysabel, Ryan S. Anderton, Jodie L. Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri, and Nicolas H. Hart. 2021. "Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study" Sports 9, no. 2: 22. https://doi.org/10.3390/sports9020022

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